{"id":10143,"date":"2026-05-18T13:11:18","date_gmt":"2026-05-18T11:11:18","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2026\/13\/stefanini-lucia\/"},"modified":"2026-07-14T09:43:11","modified_gmt":"2026-07-14T07:43:11","slug":"stefanini-lucia","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2026\/13\/stefanini-lucia\/","title":{"rendered":"Stefanini Lucia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10143\" class=\"elementor elementor-10143 elementor-9623\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Lucia Stefanini<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"717\" height=\"1024\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/STEFANINI-717x1024.jpg\" class=\"attachment-large size-large wp-image-10145\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/STEFANINI-717x1024.jpg 717w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/STEFANINI-210x300.jpg 210w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/STEFANINI-768x1096.jpg 768w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/STEFANINI-359x513.jpg 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/STEFANINI.jpg 1162w\" sizes=\"(max-width: 717px) 100vw, 717px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor <\/h3><p class=\"elementor-image-box-description\">lucia.stefanini@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f67f05 elementor-widget elementor-widget-heading\" data-id=\"8f67f05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ec1221 elementor-widget elementor-widget-text-editor\" data-id=\"1ec1221\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>2012-2013 Research Assistant Professor Biochemistry and Biophysics University of North Carolina, Chapel Hill, USA<\/li><li>2013-2015 Senior Research Fellow Institute for Cardiovascular and Metabolic Research University of Reading, Reading, United Kingdom<\/li><li>2016 \u2013 2019 Assistant Professor Internal Medicine and Medical Specialties Sapienza University of Rome, Rome, Italy<\/li><li>2019 \u2013 present Associate Professor Translational and Precision Medicine Sapienza University of Rome, Rome, Italy<\/li><li>2023-2024 Visiting Professor Immunology Boston Children\u2019 Hospital Harvard Medical School, Boston, USA<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24fb7c0 elementor-widget elementor-widget-heading\" data-id=\"24fb7c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8df41d elementor-widget elementor-widget-text-editor\" data-id=\"a8df41d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>2009 Best Presentation American Society of Hematology Research Presentation at ASH Annual Meeting<\/li>\n<li>2009 Travel Award American Society of Hematology Travel Award<\/li>\n<li>2009 Best Presentation Thomas Jefferson University Research Presentation at Postdoctoral Symposium<\/li>\n<li>2009 Travel Fellowship Thomas Jefferson University Travel Fellowship<\/li>\n<li>2010 Best Presentation Thomas Jefferson University Research Presentation at Postdoctoral Symposium<\/li>\n<li>2011 New Investigator Travel Award for International Society of Thrombosis and Haemostasis Travel Award<br\/><\/li>\n<li>2013 Research Council Spring Award University of North Carolina Research<\/li>\n<li>2013 Young Investigator Award International Society of Thrombosis and Haemostasis Research<\/li>\n<li>2013 Kenneth M. Brinkhous Young Investigator Prize in Thrombosis America Heart Association Research<\/li>\n<li>2015 Young Investigator Award International Society of Thrombosis and Haemostasis Research<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4133558 elementor-widget elementor-widget-heading\" data-id=\"4133558\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests \n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fd5faa elementor-widget elementor-widget-text-editor\" data-id=\"7fd5faa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Immunothrombosis, crosstalk between platelets and immunity, role of platelets in modulating local and systemic inflammation, pathophysiological mechanisms of tissue repair and fibrosis.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ddad65 elementor-widget elementor-widget-heading\" data-id=\"3ddad65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b500ea9 elementor-widget elementor-widget-text-editor\" data-id=\"b500ea9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>&#8211; Dissection of the signaling pathways controlling integrin activation in platelets and their relationship to the kinetics of platelet adhesion and aggregation in the presence of flow<br\/>&#8211; Identification of RASA3, the molecule that controls sustained platelet activation downstream of P2Y12 receptor, the main target of currently used anti-thrombotic drugs<br\/>&#8211; Identification of a platelet-B cell crosstalk after vaccination<br\/>&#8211; Identification of a platelet-NK crosstalk in the gut-brain axis that controls memory.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b544dde elementor-widget elementor-widget-heading\" data-id=\"b544dde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected Publications\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5e862c elementor-widget elementor-widget-text-editor\" data-id=\"d5e862c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>1. Garofalo S, Mormino A, Mazzarella L, Cocozza G, Rinaldi A, Di Pietro E, Di Castro MA, De Felice E, Maggi L, Chece G, Andolina D, Ventura R, Ielpo D, Piacentini R, Catalano M, <strong>Stefanini L<\/strong>, Limatola C. Platelets tune fear memory in mice. <strong>Cell Rep 2025<\/strong>, Feb 25;44(2):115261.<\/p><p>2. Distinct platelet crosstalk with adaptive and innate immune cells after adenoviral and mRNA vaccination against SARS-CoV-2. Lombardi L, Maiorca F, Marrapodi R, Sabetta A, Scafa N, Pallucci D, Miglionico M, Romiti GF, Corica B, Piconese S, Polimeni A, Pulcinelli F, Cangemi R, Visentini M, Basili S, <strong>Stefanini L<\/strong>. J Thromb Haemost. 2023 Jun;21(6):1636-1649.   <\/p><p>3. <strong>Stefanini L<\/strong>, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W. RASA3 is a critical inhibitor of RAP1-dependent platelet activation. <em><strong>Journal of Clinical Investigation<\/strong><\/em>. <strong>2015<\/strong> Apr;125(4):1419-32. <\/p><p>4. <strong>Stefanini L<\/strong>, Ye F, Snider AK, Sarabakhsh K, Piatt R, Paul DS, Bergmeier W, Petrich BG. A talin mutant that impairs talin-integrin binding in platelets decelerates \u03b1IIb\u03b23 activation without pathological bleeding. <strong>Blood. 2014<\/strong> Apr 24;123(17):2722-31.  <\/p><p>5. <strong>Stefanini L<\/strong>, Roden RC, Bergmeier W. CalDAG-GEFI is at the nexus of calcium-dependent platelet activation. <strong>Blood. 2009<\/strong>, Sep 17; 114(12): 2506-14.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title<\/td>\n        <td>Funding Source<\/td>\n        <td>Amount (Euros)<\/td>\n        <td>Period<\/td>\n        <td>Role of the PI<\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Implementing new technological platforms to monitor the thrombotic risk of patients with infectious disease.\n<\/td>\n        <td>Sapienza University of Rome\n<\/td>\n        <td>48,000<\/td>\n        <td>2024-2026\n<\/td> <td>PI (10% of time)<\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n         <td>Characterization of the platelet inflammatory response in NAFL and NASH.\n\n<\/td>\n        <td>Merck Sharp & Dohme Llc\n\n<\/td>\n        <td>96,000<\/td>\n        <td>2021-2025\n<\/td> <td>Scientific Coordinator (20% of time)<\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Programmed platelet death in Metabolic dysfunction-associated fatty liver disease.<\/td> <td>Istituto Pasteur Cenci Bolognetti<\/td>\n        <td>40,000<\/td>\n        <td>2025-2027<\/td>\n        <td>PI (20% of time)<\/td><\/tr>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Complete list of published work<\/strong> <strong>in MyBibliography:<\/strong><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=stefanini+lucia&#038;sort=date\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=stefanini+lucia&#038;sort=date<\/a><\/p><p><strong>KEYWORDS<\/strong><\/p><p>Platelets, immunothrombosis, fibrosis, inflammosome<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Lucia Stefanini Associate Professor lucia.stefanini@uniroma1.it Academic Appointments 2012-2013 Research Assistant Professor Biochemistry and Biophysics University of North Carolina, Chapel Hill, USA 2013-2015 Senior Research Fellow Institute for Cardiovascular and Metabolic Research University of Reading, Reading, United Kingdom 2016 \u2013 2019 Assistant Professor Internal Medicine and Medical Specialties Sapienza University of Rome, Rome, Italy 2019 \u2013 &hellip;<\/p>\n","protected":false},"author":10,"featured_media":10144,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10143"}],"version-history":[{"count":7,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10143\/revisions"}],"predecessor-version":[{"id":10541,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10143\/revisions\/10541"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10144"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}