{"id":10199,"date":"2026-05-11T15:54:35","date_gmt":"2026-05-11T13:54:35","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2026\/15\/scagnolari-carolina\/"},"modified":"2026-08-26T11:07:32","modified_gmt":"2026-08-26T09:07:32","slug":"scagnolari-carolina","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2026\/15\/scagnolari-carolina\/","title":{"rendered":"Scagnolari Carolina"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10199\" class=\"elementor elementor-10199 elementor-9470\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Carolina Scagnolari<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"724\" height=\"1024\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/Progetto-senza-titolo-1-724x1024.jpg\" class=\"attachment-large size-large wp-image-10201\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/Progetto-senza-titolo-1-724x1024.jpg 724w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/Progetto-senza-titolo-1-212x300.jpg 212w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/Progetto-senza-titolo-1-768x1086.jpg 768w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/Progetto-senza-titolo-1-359x508.jpg 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2026\/05\/Progetto-senza-titolo-1.jpg 1414w\" sizes=\"(max-width: 724px) 100vw, 724px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Full Professor of Microbiology and Clinical Microbiology <\/h3><p class=\"elementor-image-box-description\">carolina.scagnolari@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f67f05 elementor-widget elementor-widget-heading\" data-id=\"8f67f05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ec1221 elementor-widget elementor-widget-text-editor\" data-id=\"1ec1221\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>2002 Single-cycle Master&#8217;s degree (110\/100 cum laude)<\/li><li>2006 PhD in Experimental Medicine Sapienza University of Rome<\/li><li>2008 Specialization in Microbiology and Virology (70\/70 cum laude)<\/li><li>2010-2017 Assistant Professor at the Department of Molecular Medicine, Sapienza University of Rome<\/li><li>2018-2024 Associate Professor at the Department of Molecular Medicine, Sapienza University of Rome<\/li><li>2016-2022 Chair of the Bachelor Degree program in Nursing (course T), Sapienza University of Rome<\/li><li>2019-ongoing Member of the Scientific Board of PhD in Life Science, Sapienza University of Rome<\/li><li>2020-ongoing Director of the Master in Molecular Virology (II level), Sapienza University of Rome<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24fb7c0 elementor-widget elementor-widget-heading\" data-id=\"24fb7c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a8df41d elementor-widget elementor-widget-text-editor\" data-id=\"a8df41d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2022 ICAR-Conference on Retroviruses and Opportunistic Infections (CROI) Awards (2014; 2015) for oral presentations.<br\/>\u2022 Special Jury Prize 2014 released by Prof. G. Silvestri, Prof B.H Hahn and Prof GS Deeks for the best oral communication at the CROI, Boston, USA.<br\/>\u2022 Gilead Award, 2016 (HIV Fellowship Program) \u2013 Project: &#8216;Integrative model combining immunogenetics, viral burden, and cardiovascular disease in HIV-1 patients.&#8217;<br\/>\u2022 Gilead Award, 2021 (HIV Fellowship Program) \u2013 Project on integrative monitoring of SARS-CoV-2 infection- vs vaccine-induced immunity in HIV-1 patients.<br\/>\u2022 Mentor of ICAR-CROI award-winning presenters (2021\u20132024)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4133558 elementor-widget elementor-widget-heading\" data-id=\"4133558\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests \n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7fd5faa elementor-widget elementor-widget-text-editor\" data-id=\"7fd5faa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The following topics are the focus of my research interest:<br\/>\u2022 The antiviral activity of type I\u2013III IFNs and pattern recognition receptor pathway modulators against emerging viruses, and the in vitro characterization of viral immune-evasion strategies;<br\/>\u2022 Regulation of IFN production, inflammatory signaling and immune cell subsets in viral infectious diseases;<br\/>\u2022 The biological and clinical significance of autoantibodies against IFN;<br\/>\u2022 Genetic variability of the 3&#8242; UTR of mosquito-borne orthoflaviviruses and the immunopathogenic role of non-coding sfRNAs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ddad65 elementor-widget elementor-widget-heading\" data-id=\"3ddad65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b500ea9 elementor-widget elementor-widget-text-editor\" data-id=\"b500ea9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Over the years, C. Scagnolari has focused on host\u2013virus interactions at the cellular and molecular level, with particular attention to viruses and interferons (IFNs). During the 2003 severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) outbreak, she was among the first to describe viral resistance to IFN action. Her work expanded to IFN activity against emerging viruses, including human metapneumovirus (HMPV), influenza A(H1N1), arboviruses, SARS-CoV-2, and monkeypox virus. She showed that IFNs, while antiviral, can be detrimental when persistently expressed in acute and chronic viral infections. Her research includes Toll-like receptors, type I\/III IFNs, and interferon-stimulated genes in human immunodeficiency virus type 1 (HIV-1), human papillomavirus (HPV), dengue virus, respiratory viral infections, and long COVID. She identified anti-IFN autoantibodies in severe COVID-19, HIV-1\/SARS-CoV-2 coinfection, and West Nile virus infection. She also contributed to studies on the molecular epidemiology and genetic diversity of respiratory viruses, HPV, and arboviruses.      <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b544dde elementor-widget elementor-widget-heading\" data-id=\"b544dde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications\n\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d5e862c elementor-widget elementor-widget-text-editor\" data-id=\"d5e862c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Bordi L, D&#8217;Auria A, Frasca F, Mazzotta V, Mazzetti P, Fracella M, d&#8217;Ettorre G, Antonelli G, Pistello M, Antinori A, Viscidi RP, Maggi F, Lalle E, <strong>Scagnolari C<\/strong>. MPXV infection impairs IFN response but is partially sensitive to IFN-\u03b3 antiviral effect Med Microbiol Immunol. 2024;213(1):25. doi: 10.1007\/s00430-024-00808-w.   <\/p><p>Fracella M, Mancino E, Nenna R, Virgillito C, Frasca F, D&#8217;Auria A, Sorrentino L, Petrarca L, La Regina D, Matera L, Di Mattia G, Caputo B, Antonelli G, Pierangeli A, Viscidi RP, Midulla F, <strong>Scagnolari C<\/strong>. Age-related transcript changes in type I interferon signaling in children and adolescents with long COVID. Eur J Immunol. 2024:e2350682. doi: 10.1002\/eji.202350682.<\/p><p>Pierangeli A, Gentile M, Oliveto G, Frasca F, Sorrentino L, Matera L, Nenna R, Viscido A, Fracella M, Petrarca L, D&#8217;Ettorre G, Ceccarelli G, Midulla F, Antonelli G, <strong>Scagnolari C<\/strong>. Comparison by Age of the Local Interferon Response to SARS-CoV-2 Suggests a Role for IFN-\u03b5 and -\u03c9. Front Immunol. 2022;13:873232. doi: 10.3389\/fimmu.2022.873232.<\/p><p>Frasca F, Scordio M, Santinelli L, Gabriele L, Gandini O, Criniti A, Pierangeli A, Angeloni A, Mastroianni CM, d&#8217;Ettorre G, Viscidi RP, Antonelli G, <strong>Scagnolari C<\/strong>. Anti-IFN-\u03b1\/-\u03c9 neutralizing antibodies from COVID-19 patients correlate with downregulation of IFN response and laboratory biomarkers of disease severity. Eur J Immunol. 2022;52(7):1120-1128. doi: 10.1002\/eji.202249824.<\/p><p>Upasani V, <strong>Scagnolari C<\/strong>, Frasca F, Smith N, Bondet V, Vanderlinden A, Lay S, Auerswald H, Heng S, Laurent D, Ly S, Duong V, Antonelli G, Dussart P, Duffy D, Cantaert T. Decreased Type I Interferon Production by Plasmacytoid Dendritic Cells Contributes to Severe Dengue. Front Immunol. 2020;11:605087. doi: 10.3389\/fimmu.2020.605087.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Unravelling the interplay of cellular and viral non-coding RNAs with the interferon response in dengue virus infection: a comprehensive in vitro and in vivo molecular\n<\/td>\n        <td>CALL 2024 Two year \"Anna Tramontano\"\n<\/td>\n        <td>40,000<\/td>\n        <td>2025-2027\n<\/td> <td>PI (25% of time)<\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n         <td>In vitro characterization of non-coding RNAs and inflammatory responses in neurotropic West Nile and Zika virus infections\n\n<\/td>\n        <td>Progetti di Ricerca (Piccoli, Medi) - Progetti Medi\n\n<\/td>\n        <td>10,000<\/td>\n        <td>2024-2026\n<\/td> <td>PI (10% of time)<\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Complete list of published work<\/strong> <strong>in MyBibliography:<\/strong><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=sCAGNOLARI+C\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=sCAGNOLARI+C<\/a><\/p><p><strong>KEYWORDS<\/strong><\/p><p>VIRUS, IFN, ANTI-IFN NAB, ARBOVIRUS, HIV, HPV<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Carolina Scagnolari Full Professor of Microbiology and Clinical Microbiology carolina.scagnolari@uniroma1.it Academic Appointments 2002 Single-cycle Master&#8217;s degree (110\/100 cum laude) 2006 PhD in Experimental Medicine Sapienza University of Rome 2008 Specialization in Microbiology and Virology (70\/70 cum laude) 2010-2017 Assistant Professor at the Department of Molecular Medicine, Sapienza University of Rome 2018-2024 Associate Professor at the &hellip;<\/p>\n","protected":false},"author":10,"featured_media":9869,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10199","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/10"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10199"}],"version-history":[{"count":7,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10199\/revisions"}],"predecessor-version":[{"id":11503,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10199\/revisions\/11503"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/9869"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}