{"id":10610,"date":"2025-05-28T17:43:57","date_gmt":"2025-05-28T15:43:57","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/17\/piconese-silvia\/"},"modified":"2026-07-15T16:53:35","modified_gmt":"2026-07-15T14:53:35","slug":"piconese-silvia","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/17\/piconese-silvia\/","title":{"rendered":"Piconese Silvia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10610\" class=\"elementor elementor-10610 elementor-8231\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Silvia Piconese<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Piconese-Silvia.png\" class=\"attachment-full size-full wp-image-10608\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Piconese-Silvia.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Piconese-Silvia-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Piconese-Silvia-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Piconese-Silvia-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Piconese-Silvia-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor<\/h3><p class=\"elementor-image-box-description\">silvia.piconese@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-25a4f46 elementor-widget elementor-widget-heading\" data-id=\"25a4f46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ea9f763 elementor-widget elementor-widget-text-editor\" data-id=\"ea9f763\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2004 MSc Medical Biotechnologies, University of Milan<\/li><li class=\"p2\"><span class=\"s1\">2008 PhD <\/span>Life and Biomolecular Sciences, Open University<\/li><li class=\"p1\">2017 Tenure-track position at Sapienza University of Rome<\/li><li class=\"p2\">2019 Junior Fellow of SSAS (Sapienza Advanced Superior School)<\/li><li class=\"p1\"><span class=\"s2\">2020 Associate Professor <\/span>at Sapienza University of Rome<\/li><li class=\"p2\"><span class=\"s1\">2022 <\/span>National academic qualification as full professor in General Pathology, Laboratory Medicine<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-37db483 elementor-widget elementor-widget-heading\" data-id=\"37db483\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Award<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31e98dd elementor-widget elementor-widget-text-editor\" data-id=\"31e98dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2010 \u201cGuido Berlucchi\u201d prize for young researchers in oncology, \u201cGuido Berlucchi\u201d Foundation, Brescia<\/li><li class=\"p1\">2009 \u201cCecilia Cioffrese\u201d prize for young researchers in the fields of oncology and viral diseases, \u201cCarlo Erba\u201d Foundation, Milan<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8e6be30 elementor-widget elementor-widget-heading\" data-id=\"8e6be30\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9797c6d elementor-widget elementor-widget-text-editor\" data-id=\"9797c6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Fundamental and translational immunology. Regulatory T cell dynamics in physiology and pathology. T cell responses in oncoimmunology. Immunometabolism, iron metabolism and lipid metabolism in lymphocytes and monocytes.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-16c5ec4 elementor-widget elementor-widget-heading\" data-id=\"16c5ec4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39f2eff elementor-widget elementor-widget-text-editor\" data-id=\"39f2eff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"ul1\"><li class=\"li1\">discovery that Tregs require iron for their proliferation post-birth and in cancer<\/li><li class=\"li1\">description of Treg expansion in a genetic hypolipidemia<\/li><li class=\"li1\">demonstration of a glycolytic-lipogenic circuit governing Treg expansion in cancer<\/li><li class=\"li1\">observation that type I interferons can modulate Treg dynamics in autoimmunity<\/li><li class=\"li1\">description of CD8 T cells specific to apoptosis-associated antigens in chronic viral infections and autoimmunity<\/li><li class=\"li1\">study of OX40 in effector Treg expansion in human cancers<\/li><li class=\"li1\">characterization of OX40 in Treg function, expansion, and interaction with mast cells<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3742159 elementor-widget elementor-widget-heading\" data-id=\"3742159\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Selected publications<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f30ca9 elementor-widget elementor-widget-text-editor\" data-id=\"7f30ca9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"ol1\"><li class=\"li1\">Pacella I, [\u2026] <strong>PICONESE S<\/strong>. Iron capture through CD71 drives perinatal and tumor-associated Treg expansion. JCI Insight. 2024 Jul 2;9(15):e167967.<\/li><li class=\"li1\">Pinzon Grimaldos, A., [\u2026] <strong>PICONESE S<\/strong>. ANGPTL3 deficiency associates with the expansion of regulatory T cells with reduced lipid content. Atherosclerosis 2022 Dec;362:38-46.  <\/li><li class=\"li1\">Pacella I, [\u2026] <strong>PICONESE S<\/strong>. ISG15 protects human Tregs from interferon alpha-induced contraction in a cell-intrinsic fashion. Clin Transl Immunology. 2020 Dec 23;9(12):e1221.   <\/li><li class=\"li1\">Pacella I, [\u2026] <strong>PICONESE S<\/strong>. Wnt3a neutralization enhances T-cell responses through indirect mechanisms and restrains tumor growth Cancer Immunol Res. 2018 Aug;6(8):953-964. <\/li><li class=\"li1\">Pacella I, [\u2026] <strong>PICONESE S<\/strong>. Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6546-E6555.  <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title<\/td>\n        <td>Funding source<\/td>\n        <td>Amount (Euros)<\/td>\n        <td>Period<\/td>\n        <td>Role of the PI<\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Ironic Tregs: competition for iron between Tregs and microbiota in cancer <\/td>\n<td>Istituto Pasteur Italia, Fondazione Cenci Bolognetti <\/td>\n<td>40.000 <\/td>\n<td>2025-2027\n<\/td>\n<td>PI (50 % of time)<\/td>\n    <\/tr>\n        <tr class=\"ricercatori-table-row\">\n        <td>T-OXic: CD4 T cell-intrinsic roles of BRCA1 in oxidative stress resistance in triple-negative breast cancer\n<\/td>\n<td>AIRC (Italian Association for Cancer Research)<\/td>\n<td>540.000 <\/td>\n<td>2023-2027\n<\/td>\n<td>PI (50 % of time)<\/td>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=piconese+s\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=piconese+s<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Treg, immunometabolism, tumor immunology.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Silvia Piconese Associate Professor silvia.piconese@uniroma1.it Academic Appointments 2004 MSc Medical Biotechnologies, University of Milan 2008 PhD Life and Biomolecular Sciences, Open University 2017 Tenure-track position at Sapienza University of Rome 2019 Junior Fellow of SSAS (Sapienza Advanced Superior School) 2020 Associate Professor at Sapienza University of Rome 2022 National academic qualification as full professor in &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10609,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10610","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10610","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10610"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10610\/revisions"}],"predecessor-version":[{"id":10611,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10610\/revisions\/10611"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10609"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10610"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10610"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10610"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}