{"id":10614,"date":"2025-06-04T11:38:08","date_gmt":"2025-06-04T09:38:08","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/11\/dalessandro-giuseppina\/"},"modified":"2026-07-15T17:12:16","modified_gmt":"2026-07-15T15:12:16","slug":"dalessandro-giuseppina","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/11\/dalessandro-giuseppina\/","title":{"rendered":"D&#8217;Alessandro Giuseppina"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10614\" class=\"elementor elementor-10614 elementor-8437\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Giuseppina D'Alessandro<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Dalessandro-1.png\" class=\"attachment-full size-full wp-image-9975\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Dalessandro-1.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Dalessandro-1-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Dalessandro-1-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Dalessandro-1-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Dalessandro-1-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor<\/h3><p class=\"elementor-image-box-description\">giuseppina.dalessandro@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-13a0a34 elementor-widget elementor-widget-heading\" data-id=\"13a0a34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b5d292b elementor-widget elementor-widget-text-editor\" data-id=\"b5d292b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2023-present University of Rome \u201cSapienza\u201d: Associate professor<\/li><li class=\"p1\">2020-2023 University of Rome \u201cSapienza\u201d: RTD-B<\/li><li class=\"p1\">05\/2019 Ministry of University and Research: National Academic Qualification as Associate Professor<\/li><li class=\"p1\">2018-present University of Rome \u201cSapienza\u201d as Teacher of Human Physiology<\/li><li class=\"p1\">2018-2020 University of Rome \u201cSapienza\u201d as Researcher RTD-A<\/li><li class=\"p1\">2018-2019 G.B. Baroni Foundation as Research Fellow<\/li><li class=\"p1\">07\/2017 Lancaster University as Visiting Researcher<\/li><li class=\"p1\">2016- present IRCCS Neuromed as Research Fellow<\/li><li class=\"p1\">2016 Ministry of Health Granted as Principal Investigator Under 40 Research Program<\/li><li class=\"p1\">2013 University of Rome \u201cSapienza\u201d: PhD in Neurophysiology<\/li><li class=\"p1\">2012- 2018 University of Rome \u201cSapienza\u201d as Post-doc<\/li><li class=\"p1\">2009-2012 University of Rome \u201cSapienza\u201d as PhD Student<\/li><li class=\"p1\">2008 Mario Negri Institute of Milan: Specialization in Pharmacology Research<\/li><li class=\"p1\">2005-2009 Mario Negri Institute of Milan as Research Fellow<\/li><li class=\"p1\">2004 University of Naples \u201cFederico II\u201d: Biotechnology degree<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5cc7aec elementor-widget elementor-widget-heading\" data-id=\"5cc7aec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-41fcf31 elementor-widget elementor-widget-text-editor\" data-id=\"41fcf31\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Investigate the role of innate and adaptive immunity in glioma progression and the cellular and molecular mechanisms involved in the glial phenotype in brain disorders.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f3aa90f elementor-widget elementor-widget-heading\" data-id=\"f3aa90f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6583a2 elementor-widget elementor-widget-text-editor\" data-id=\"b6583a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">I)Identification of the role of Ca2+ activated K+ channels (KCa3.1) in cell migration, invasion and proliferation of malignant glioma and in modulating phenotype of glioma associated microglia\/macrophage cells.<\/p><p class=\"p1\">II) Identification of the role of voltage-gated potassium channel Kv1.3 in modulating inflammation and mitochondrial degeneration in mutant SOD1 mice.<\/p><p class=\"p1\">III) Identification of the role of microbiota composition in modulate brain innate immune cell state in physiological and glioma context.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e2cca71 elementor-widget elementor-widget-heading\" data-id=\"e2cca71\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-670c62f elementor-widget elementor-widget-text-editor\" data-id=\"670c62f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"ol1\"><li class=\"li1\">Rosito M, Maqbool J, Reccagni A, Giampaoli O, Sciubba F , Antonangeli F , Scavizzi F , Raspa M , Cordella F, Tondo L, Di Angelantonio S, Trettel F, Miccheli A, <span class=\"s1\"><strong>D&#8217;Alessandro Giuseppina<\/strong>*<\/span>, Limatola C*. Antibiotics treatment promotes vasculogenesis in the brain of glioma-bearing mice. C<span class=\"s2\">ell Death Dis. 2024 Mar 13;15(3):210. doi: 10.1038\/s41419-024-06578-w.<\/span>  <\/li><li class=\"li1\"><strong><span class=\"s1\">D&#8217;Alessandro Giuseppina<\/span><\/strong>, et al. Gut microbiota alterations affect glioma growth and innate immune cells involved in tumor immunosurveillance in mice. Eur J Immunol. 2020 Feb 8. doi: 10.1002\/eji.201948354<\/li><li class=\"li1\">Ratano P, Cocozza G, Pinchera C, Busdraghi LM, Cantando I, Martinello K, Scioli M, Rosito M, Bezzi P, Fucile S, Wulff H, Limatola C, <strong><span class=\"s1\">D\u2019Alessandro Giuseppina<\/span><\/strong>. Reduction of Inflammation and Mitochondrial Degeneration in Mutant SOD1 Mice through Inhibition of Voltage-Gated Potassium Channel Kv1.3. <span class=\"s2\">Front Mol Neurosci. 2024 Jan 16;16:1333745. doi: 10.3389\/fnmol.2023.1333745. <\/span>  <\/li><li class=\"li1\">Massenzio F, Cambiaghi M, Marchiotto F, Boriero D, Limatola C , <strong><span class=\"s1\">D\u2019Alessandro Giuseppina<\/span>*<\/strong>, and Buffelli *. In vivo morphological alterations of TAMs during KCa3.1 inhibition by using in vivo two-photon time-lapse technology. Front. Cell. Neurosci. 2022, 16:1002487<\/li><li class=\"li1\"><strong><span class=\"s1\">Giuseppina D\u2019Alessandro<\/span><\/strong>, et al. Radiation Increases KCa3.1 Functional Expression and Invasiveness in Glioblastoma. Cancers (Basel). 2019 Feb 26;11(3):279. doi: 10.3390\/cancers11030279.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title<\/td>\n        <td>Funding source<\/td>\n        <td>Amount (Euros)<\/td>\n        <td>Period<\/td>\n        <td>Role of the PI<\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>\u201cTargeting the immunosuppressive microenvironment of glioma through a novel dendritic cell vaccination\u201d\n <\/td>\n        <td>ISTITUTO PASTEUR ITALIA - FOND. CENCI BOLOGNETTI \n\n <\/td>\n        <td>40.000  <\/td>\n        <td>2025-2027\n <\/td> <td>PI ( 30% of time) <\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n         <td>\u201cExploiting the natural antigen specific response to selected bacteria to counteract glioblastoma progress\u201d\n<\/td>\n<td>RICERCA SAPIENZA-ROME TECHNOPOLE FOR THE INTERNATIONALISATION OF RESEARCH' FUNDING LINE 1\n\n<\/td>\n<td>20.000 <\/td>\n<td>2024-2025\n<\/td> <td>PI (30 % of time)<\/td><\/tr>\n  \n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=D%27Alessandro+Giuseppina&#038;sort=date&#038;sort_order=asc\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=D%27Alessandro+Giuseppina&#038;sort=date&#038;sort_order=asc<\/a><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Glioma; Innate immunity; Immunotherapy; Gut microbiota.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Giuseppina D&#8217;Alessandro Associate Professor giuseppina.dalessandro@uniroma1.it Academic Appointments 2023-present University of Rome \u201cSapienza\u201d: Associate professor 2020-2023 University of Rome \u201cSapienza\u201d: RTD-B 05\/2019 Ministry of University and Research: National Academic Qualification as Associate Professor 2018-present University of Rome \u201cSapienza\u201d as Teacher of Human Physiology 2018-2020 University of Rome \u201cSapienza\u201d as Researcher RTD-A 2018-2019 G.B. Baroni Foundation as &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10613,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10614","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10614","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10614"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10614\/revisions"}],"predecessor-version":[{"id":10615,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10614\/revisions\/10615"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10613"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10614"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10614"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10614"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}