{"id":10616,"date":"2025-06-05T11:30:51","date_gmt":"2025-06-05T09:30:51","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/11\/mozzetta-chiara\/"},"modified":"2026-07-16T13:09:19","modified_gmt":"2026-07-16T11:09:19","slug":"mozzetta-chiara","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/11\/mozzetta-chiara\/","title":{"rendered":"Mozzetta Chiara"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10616\" class=\"elementor elementor-10616 elementor-8471\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Chiara Mozzetta<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Mozzetta.png\" class=\"attachment-full size-full wp-image-10604\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Mozzetta.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Mozzetta-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Mozzetta-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Mozzetta-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/Mozzetta-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor<\/h3><p class=\"elementor-image-box-description\">chiara.mozzetta@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1485cd5 elementor-widget elementor-widget-heading\" data-id=\"1485cd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3afbad1 elementor-widget elementor-widget-text-editor\" data-id=\"3afbad1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\"><span class=\"Apple-converted-space\">  <\/span>2024-to date &#8211; Associate Professor, Dept. of Biology and Biotechnology \u201cC. Darwin\u201d. University Sapienza of Rome, (Italy).  <\/li><li class=\"p1\">2019-2024 Principal Investigator, Tenured Researcher, Institute of Molecular Biology and Pathology (IBPM) &#8211; National Research Council (CNR), Rome, (Italy).<\/li><li class=\"p1\">2016- 2018 Principal Investigator, Lecturer, Dept. of Biology and Biotechnology \u201cC. Darwin\u201d. University Sapienza of Rome, (Italy).  <\/li><li class=\"p1\">2013-2016 Senior Post-doc, Institute of Cell Biology and Neurobiology (IBCN), CNR, Rome (Italy). Dr. Lanzuolo lab <\/li><li class=\"p1\">2010- 2013 Post-doc at UMR7216 CNRS\/University Paris Diderot, Paris (France). Dr. Ait-Si-Ali lab <\/li><li class=\"p1\">2009- 2010 Post-doc at IRCCS Fondazione Santa Lucia, Rome, (Italy). Dr. Puri lab <\/li><li class=\"p1\">2009- 2009 Visiting Research Scientist at Sanford-Burnham for Medical Research, La Jolla (CA, USA). Dr. Puri lab <\/li><li class=\"p1\">2008- 2008 Visiting PhD fellow, University Pierre et Marie, Paris (France). Dr. Sassoon lab <\/li><li class=\"p1\">2006- 2007 Visiting PhD student at Sanford-Burnham for Medical Research, La Jolla (CA, USA). Dr. Puri lab <\/li><li class=\"p1\">2005- 2009 Post-graduate and PhD fellow, Dulbecco Telethon Institute (DTI), IRCCS Fondazione Santa Lucia and European Brain Research Institute (Italy). Dr. Puri lab <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4cf73f elementor-widget elementor-widget-heading\" data-id=\"b4cf73f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4417136 elementor-widget elementor-widget-text-editor\" data-id=\"4417136\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2011-2013 EMBO Long-term post-doc Fellowship<\/li><li class=\"p1\">2011-2011 FRM (Fondation pour la Recherche M\u00e9dicale), short-term post-doc fellowship<\/li><li class=\"p1\">2009\/2010 Post-doc fellowships granted by AFM (Association Fran\u00e7aise contre les Myopathies)<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efabbc4 elementor-widget elementor-widget-heading\" data-id=\"efabbc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f6c077 elementor-widget elementor-widget-text-editor\" data-id=\"5f6c077\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Our laboratory investigates the epigenetic mechanisms governing muscle progenitor cell fate under normal physiological conditions and in pathological states such as muscular dystrophies and rhabdomyosarcomas (RMS). Specifically, we study how chromatin dynamics and nuclear architecture influence cell identity and behavior. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-50cd373 elementor-widget elementor-widget-heading\" data-id=\"50cd373\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science <\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c83d3ca elementor-widget elementor-widget-text-editor\" data-id=\"c83d3ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">We identified <i>Prdm16<\/i> as a key regulator of fibro-adipogenic progenitors (FAPs), maintaining their identity by tethering heterochromatin to the nuclear lamina and organizing lamina-associated domains (LADs) (Biferali et al., <i>Sci Adv<\/i> 2021). We also mapped LADs and H3K9me2-enriched domains (KDDs) in FAPs for the first time. <\/p><p class=\"p1\">Following up my previous studies on H3K9 methyltransferases (Mozzetta et al., <i>Mol Cell <\/i>2014; Mozzetta et al., <i>Nat Rev Mol Cell Biol<\/i>, 2015), we discovered that G9a, via the lncRNA <i>Rewind<\/i>, promotes muscle stem cell proliferation by repressing <i>Wnt7b<\/i> through H3K9me2 deposition (Cipriano et al., <i>eLife<\/i> 2021). We also demonstrated that in alveolar rhabdomyosarcoma (RMS), G9a supports tumor survival by partnering with DDX5 to sustain <i>PAX3-FOXO1<\/i> expression (Gualtieri et al., <i>Cell Rep<\/i> 2022); DDX5 also regulates circRNA production in RMS (Dattilo et al., <i>Nat Commun<\/i> 2023).<br\/>Our epigenomic work opens therapeutic avenues in muscle diseases, aligning with the FDA&#8217;s recent approval of HDAC inhibitors for DMD\u2014an effort grounded in our earlier preclinical studies (Mozzetta et al., <i>EMBO Mol Med<\/i> 2013; Saccone et al <i>G&#038;D<\/i>, 2014; reviewed in <i>Trends Mol Med<\/i> 2024). <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a37b4cd elementor-widget elementor-widget-heading\" data-id=\"a37b4cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-009865b elementor-widget elementor-widget-text-editor\" data-id=\"009865b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"ul1\"><li class=\"li1\"><strong>Mozzetta C<\/strong>, Sartorelli V, Puri PL. HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients. Trends Mol Med. 2024 Feb 25.  <\/li><li class=\"li1\">Bianconi V. and <strong><span class=\"s2\">Mozzetta C<\/span><\/strong>. Epigenetic control of muscle stem cells: time for a new dimension. <b><i>Trends in Genetics,<\/i><\/b> 2022 Jan 22. <\/li><li class=\"li1\">Biferali B., Bianconi V., Fernandez Perez D., P\u00f6hle Kronawitter S., Marullo F., Maggio R., Santini T., Polverino F., Biagioni S., Summa V., Toniatti C., Pasini D., Stricker S., Di Fabio R., Chiacchiera F., Peruzzi G., <strong><span class=\"s2\">Mozzetta C<\/span><\/strong>. Prdm16-mediated H3K9 methylation controls Fibro-Adipogenic Progenitors identity during skeletal muscle repair. <span class=\"Apple-converted-space\">  <\/span><b><i>Science Advances<\/i><\/b> 2021, 7(23), eabd9371<\/li><li class=\"li1\"><strong><span class=\"s2\">Mozzetta C<\/span><\/strong>, Boyarchuk E, Pontis J, Ait-Si-Ali S\u00a7. Sound of Silence: The properties and functions of repressive lysine methyltransferases. <b><i>Nature Review Molecular Cell Biology<\/i><\/b>. 2015 Aug;16(8):499-513.   <span class=\"s4\"><i>\u00a7 co-corresponding author<\/i><\/span><\/li><li class=\"li1\"><strong><span class=\"s2\">Mozzetta C<\/span><\/strong> , Pontis J, Fritsch L, Robin P, Portoso M, Proux C, Margueron R, Ait-Si-Ali S\u00a7 (2014). The Histone H3 Lysine 9 Methyltransferases G9a and GLP Regulate Polycomb Repressive Complex 2-Mediated Gene Silencing. <b><i>Molecular Cell<\/i><\/b>. Jan 23;53(2):277-89 Epub 2014 Jan 2.   <span class=\"s4\"><i>\u00a7 co-corresponding<\/i><\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title<\/td>\n        <td>Funding source<\/td>\n        <td>Amount (Euros)<\/td>\n        <td>Period<\/td>\n        <td>Role of the PI<\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Reprogramming of Genome-Nuclear Lamina Interactions in Fibro-Adipogenic Progenitors During Regeneration and Aging\n<\/td>\n<td>Pasteur-Cenci Bolognetti Anna Tramontano Grant\n<\/td>\n<td>40.000 <\/td>\n<td>2025-2027\n<\/td> <td>PI ( 10% of time) <\/td> <\/tr>\n    <tr class=\"ricercatori-table-row\">\n         <td>Aberrant chromatin-nuclear lamina interactions in stromal cells as underlying mechanism of rhabdomyosarcoma initiation\n<\/td>\n<td>Investigator Grant (IG) from the Italian Association for Cancer Research (AIRC)\n<\/td>\n<td>630.000 <\/td>\n<td>2023-2028\n<\/td> <td>PI (20 % of time)<\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Assessing the role of Fibro-Adipogenic Progenitors in EDMD\n<\/td>\n<td>Muscular Dystrophy Association (MDA)\n<\/td>\n<td>244.741 <\/td>\n<td>2022-2025\n<\/td> <td>PI ( 15% of time) <\/td> <\/tr>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mozzetta+Chiara&#038;sort=date\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Mozzetta+Chiara&#038;sort=date<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Muscle Stem Cells, Fibro-Adipogenic Progenitors, Skeletal Muscle, Nuclear Lamina, Epigenetics, H3K9 methylation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Chiara Mozzetta Associate Professor chiara.mozzetta@uniroma1.it Academic Appointments: 2024-to date &#8211; Associate Professor, Dept. of Biology and Biotechnology \u201cC. Darwin\u201d. University Sapienza of Rome, (Italy). 2019-2024 Principal Investigator, Tenured Researcher, Institute of Molecular Biology and Pathology (IBPM) &#8211; National Research Council (CNR), Rome, (Italy). 2016- 2018 Principal Investigator, Lecturer, Dept. of Biology and Biotechnology \u201cC. Darwin\u201d. &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10605,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10616","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10616"}],"version-history":[{"count":2,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10616\/revisions"}],"predecessor-version":[{"id":10618,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10616\/revisions\/10618"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10605"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}