{"id":10636,"date":"2025-06-03T12:02:19","date_gmt":"2025-06-03T10:02:19","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/12\/la-regina-giuseppe\/"},"modified":"2026-07-16T14:01:45","modified_gmt":"2026-07-16T12:01:45","slug":"la-regina-giuseppe","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/12\/la-regina-giuseppe\/","title":{"rendered":"La Regina Giuseppe"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10636\" class=\"elementor elementor-10636 elementor-8372\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Giuseppe La Regina<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/LaRegina-1.png\" class=\"attachment-full size-full wp-image-10634\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/LaRegina-1.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/LaRegina-1-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/LaRegina-1-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/LaRegina-1-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/06\/LaRegina-1-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco<\/h3><p class=\"elementor-image-box-description\">giuseppe.laregina@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dfee0e9 elementor-widget elementor-widget-heading\" data-id=\"dfee0e9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f9fdbc elementor-widget elementor-widget-text-editor\" data-id=\"1f9fdbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Since September 2019: Associate Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma.<\/p><p class=\"p1\">November 2008 \u2013 September 2020: Assistant Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma.<\/p><p class=\"p1\">April 2007 &#8211; November 2008: Design, synthesis and development of new inhibitors of tubulin polymerization as anticancer agents, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma (three-year grant financed by Associazione Italiana per la Ricerca sul Cancro, Milan, Italy).<\/p><p class=\"p1\">April 2005 &#8211; March 2007: Post-Doc Position, Welsh School of Pharmacy, Cardiff University, United Kingdom, Molecular modelling studies to design new inhibitors of tubulin polymerization as anticancer agents (two-year grant financed by Institute Pasteur Italy \u2013 Cenci Bolognetti Foundation, Rome, Italy).<\/p><p class=\"p1\">November 2001 &#8211; October 2004: PhD course in Medicinal Chemistry, Dipartimento di Studi Farmaceutici (Medicinal Chemistry Department), Sapienza Universit\u00e0 di Roma, Design, synthesis and development of new non-nucleoside reverse transcriptase inhibitors of HIV-1 as anti-AIDS agents.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f564110 elementor-widget elementor-widget-heading\" data-id=\"f564110\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71ce77f elementor-widget elementor-widget-text-editor\" data-id=\"71ce77f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2018: Publons Peer Review Award 2017.<\/li><li class=\"p1\">2007: Farmindustria Prize for Pharmaceutical Research &#8211; Outstanding for researching activity.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e4011b8 elementor-widget elementor-widget-heading\" data-id=\"e4011b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5f2b047 elementor-widget elementor-widget-text-editor\" data-id=\"5f2b047\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Design, synthesis and development of anti-infective, anti-cancer and central nervous system active agents; microwave-assisted synthesis and fully automated chromatography purification of heterocyclic compounds.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8ec5ad8 elementor-widget elementor-widget-heading\" data-id=\"8ec5ad8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1603c26 elementor-widget elementor-widget-text-editor\" data-id=\"1603c26\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Prof. Giuseppe La Regina is co-Author of more than 100 scientific papers published in impacted professional journals and 5 patents about design, synthesis and development of anti-infective (human immunodeficiency virus, rhinovirus, hepatitis C virus, dengue virus, coronavirus, norovirus, zika virus, Mycobacterium tuberculosis and Candida albicans), anti-cancer (tubulin and microtubules, Wnt\/beta-catenin signalling, histone demethylases, matrix metalloproteinases, B-cell lymphoma-2, carbonic anhydrase, indoleamine 2,3-dioxygenase 1, murine double minute 2 and 4 proteins, Na+\/H+ exchanger 3 regulating factor 1, growth factor receptor bound protein 2, lactate dehydrogenase, PDZ domains, apoptosis and ferroptosis) and central nervous system active (monoamine oxidases, endocannabinoid system, glycogen synthase kinase 3 beta) agents.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eac9d1a elementor-widget elementor-widget-heading\" data-id=\"eac9d1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-547c4b1 elementor-widget elementor-widget-text-editor\" data-id=\"547c4b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">Puxeddu, M.; Ling, L.; Ripa, S.; D&#8217;Ambrosio, M.; Nalli, M.; Parisi, A.; Sci\u00f2, P.; Coluccia, A.; Granese, A.; Santelli, M.; Masci, D.; Cu\u0159\u00ednov\u00e1, P.; Naro; C.; Sette, C.; Pastore, A.; Stornaiuolo, M.; Bigogno, C.; Dondio, G.; Di Magno, L.; Canettieri, G.; Liu, T.; Silvestri, R.; <strong>La Regina, G<\/strong>. Development of N-(4-(1H-Imidazol-1-yl)phenyl)-4-chlorobenzenesulfonamide, a Novel Potent Inhibitor of \u03b2-Catenin with Enhanced Antitumor Activity and Metabolic Stability. J. Med. Chem. 2024, 67, 20298\u201220314.    <\/li><li class=\"p1\">Masci, D.; Puxeddu, M.; Di Magno, L.; D&#8217;Ambrosio, M.; Parisi, A.; Nalli, M.; Bai, R.; Coluccia, A.; Sci\u00f2, P.; Orlando, V.; D&#8217;Angelo, S.; Biagioni, S.; Urbani, A.; Hamel, E.; Nocentini, A.; Filiberti, S.; Turati, M.; Ronca, R.; Kopecka, J.; Riganti, C.; Fionda, C.; Bordone, R.; Della Rocca, G.; Canettieri; G.; Supuran, C. T.; Silvestri, R.; <strong>La Regina, G<\/strong>. 4-(3-Phenyl-4-(3,4,5-trimethoxybenzoyl)-1H-pyrrol-1-yl)benzenesulfonamide, a Novel Carbonic Anhydrase and Wnt\/\u03b2-Catenin Signaling Pathway Dual-Targeting Inhibitor with Potent Activity against Multidrug Resistant Cancer Cells. J. Med. Chem. 2023, 66, 14824\u201214842.    <\/li><li class=\"p1\">Sebastiani, S.; Puxeddu, M.; Nalli, M.; Bai, R.; Altieri, L.; Rovella P.; Gaudio, E.; Trisciuoglio, D.; Spriano, F.; Lavia, P.; Fionda, C.; Masci, D.; Urbani, A.; Bigogno, C.; Dondio, G.; Hamel, E.; Bertoni, F.; Silvestri, R.; <strong>La Regina, G<\/strong>. RS6077 induces mitotic arrest and selectively activates cell death in human cancer cell lines and in a lymphoma tumor in vivo. Eur. J. Med. Chem. 2023, 246, e114997.<\/li><li class=\"p1\">Puxeddu, M.; Wu, J.; Bai, R.; D&#8217;Ambrosio, M.; Nalli, M.; Coluccia, A.; Manetto, S.; Ciogli, A.; Masci, D.; Urbani, A.; Fionda, C.; Coni, S.; Bordone R.; Canettieri, G.; Bigogno, C.; Dondio, G.; Hamel, E.; Liu, T.; Silvestri, R.; <strong>La Regina, G<\/strong>. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor. J. Med. Chem. 2022, 65, 15805\u201215818.    <\/li><li class=\"p1\">Puxeddu M.; Shen, H.; Bai, R.; Coluccia, A.; Bufano, M.; Nalli, M.; Sebastiani, J.; Brancaccio, D.; Da Pozzo, E.; Tremolanti, C.; Martini, C.; Orlando, V.; Biagioni, S.; Sinicropi, M. S.; Ceramella, J.; Iacopetta, D.; Coluccia, A. M. L.; Hamel, E.; Liu, T.; Silvestri, R.; <strong>La Regina, G<\/strong>. (corresponding Author). Discovery of pyrrole derivatives for the treatment of glioblastoma and chronic myeloid leukemia. Eur. J. Med. Chem. 2021, 221, e113532.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Targeting Wnt\/beta-catenin pathway: identification and development of selective allosteric modulators of Dishevelled and Frizzled\nproteins as a promising approach to cancer therapy (INdWNT) - 2022TPPNTK\n\n<\/td>\n<td>Call PRIN 2022, Ministero dell\u2019Universit\u00e0 e della Ricerca\n<\/td>\n<td>203.748 <\/td>\n<td>2023-2026\n<\/td> <td>PI (20% of time) <\/td> <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Tubulin inhibitors as ferroptosis inducers in cancer treatment - RG123188B4D193AE \n<\/td>\n<td>Call Research Projects 2023, Sapienza Universit\u00e0 di Roma\n<\/td>\n<td>60.840 <\/td>\n<td>2023-2026\n<\/td>\n<td>PI (20% of time) <\/td> \n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=La+Regina+G&#038;sort=date\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=La+Regina+G&#038;sort=date<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Anti-cancer agents, anti-infective agents, central nervous system active agents, drug discovery, heterocyclic compounds.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Giuseppe La Regina Associate Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco giuseppe.laregina@uniroma1.it Academic Appointments: Since September 2019: Associate Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma. November 2008 \u2013 September 2020: Assistant Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10635,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10636","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La Regina Giuseppe - Istituto Pasteur<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/12\/la-regina-giuseppe\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"La Regina Giuseppe - Istituto Pasteur\" \/>\n<meta property=\"og:description\" content=\"Giuseppe La Regina Associate Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco giuseppe.laregina@uniroma1.it Academic Appointments: Since September 2019: Associate Professor in Medicinal Chemistry, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Universit\u00e0 di Roma. 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