{"id":10640,"date":"2025-05-30T17:01:37","date_gmt":"2025-05-30T15:01:37","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/17\/raimondo-domenico\/"},"modified":"2026-07-16T14:03:20","modified_gmt":"2026-07-16T12:03:20","slug":"raimondo-domenico","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/17\/raimondo-domenico\/","title":{"rendered":"Raimondo Domenico"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10640\" class=\"elementor elementor-10640 elementor-8350\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Domenico Raimondo<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Raimondo-1.png\" class=\"attachment-full size-full wp-image-10638\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Raimondo-1.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Raimondo-1-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Raimondo-1-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Raimondo-1-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Raimondo-1-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor of Bioinformatics, Dept. Molecular Medicine \u2013 Sapienza University of Rome  <\/h3><p class=\"elementor-image-box-description\">domenico.raimondo@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9641f16 elementor-widget elementor-widget-heading\" data-id=\"9641f16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ccf6bd6 elementor-widget elementor-widget-text-editor\" data-id=\"ccf6bd6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"ul1\"><li class=\"li1\"><b>Since 2019<\/b>: Associate Professor of Bioinformatics, Sapienza University of Rome<\/li><li class=\"li1\"><b>2018-2023<\/b>: Junior Research Fellow, Sapienza School for Advanced Studies (SSAS)<\/li><li class=\"li1\"><b>Since 2024<\/b>: Board Member, PhD in \u201c<i>Bioinformatics and Computational Biology<\/i>\u201d, Sapienza<span class=\"Apple-converted-space\"> <\/span>University of Rome<\/li><li class=\"li1\"><b>Since 2017<\/b>: Board Member, PhD in \u201c<i>Genetics and Molecular Biology<\/i>\u201d, Sapienza University of Rome<\/li><li class=\"li1\"><b>2017-2023<\/b>: Faculty member of the \u201c<i>Stem cell and gene editing \u2013 U-stem<\/i>\u201d Second Level Master School at Sapienza University of Rome<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-643d509 elementor-widget elementor-widget-heading\" data-id=\"643d509\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b253cd elementor-widget elementor-widget-text-editor\" data-id=\"3b253cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">I have 20 years of experience in Protein Structure Bioinformatics and Computational Biology. My research focuses on the computational investigation of macromolecules of biomedical relevance, with particular emphasis on their structure, dynamics, and interactions, including the analysis of protein\u2013protein and protein\u2013ligand systems in both health and disease. I am actively involved in the rational design and in silico optimization of molecules with potential therapeutic applications. Additionally, I integrate bioinformatics and computational biology tools to analyze clinical datasets, with a specific focus on cancer biology, the mechanisms underlying rare diseases and immune-mediated disorders.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8c451da elementor-widget elementor-widget-heading\" data-id=\"8c451da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c28ce3 elementor-widget elementor-widget-text-editor\" data-id=\"1c28ce3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\"><b>&#8211; Therapeutic Targets in Multiple Myeloma: CD38\u2013cGAMP and Gadd45\u03b2\u2013MKK7 Interactions<\/b><\/p><p class=\"p2\">Using computational modeling integrated with experimental data, I contributed to characterizing CD38 as a direct binder and inhibitor of extracellular cGAMP, revealing a novel immunoregulatory function. I also supported the design of D-peptides targeting the Gadd45\u03b2\u2013MKK7 interaction to induce apoptosis in multiple myeloma cells, uncovering new therapeutic strategies. <\/p><p class=\"p1\"><b>&#8211; Computational Investigation of Chemerin\u2013CCRL2 Recognition and Antibody-Related Projects<\/b><\/p><p class=\"p2\">I employ advanced molecular dynamics simulations to study receptor\u2013ligand interactions, particularly in immune-related targets. My research on the CCRL2\u2013Chemerin complex, using a multiscale computational strategy that combines coarse-grained and all-atom MD simulations, provided mechanistic insights into ligand recognition and binding. I am also involved in projects related to antibodies and immune-mediated pathologies.  <\/p><p class=\"p1\"><b>&#8211; Structural Modeling of hNOX2 for Drug Discovery<\/b><\/p><p class=\"p2\">I contributed to developing a dynamic structural model of hNOX2, a key enzyme in ROS production, using advanced simulations of membrane protein complexes and molecular docking experiments. This model is now being used as a platform for in silico screening of potential NOX2 inhibitors. <\/p><p class=\"p1\"><b>&#8211; Pin1\u2013Notch3 Interaction in Ovarian Cancer Chemoresistance<\/b><\/p><p class=\"p2\">Using molecular dynamics approch and advanced structural bioinformatics tools, I analyzed the Pin1\u2013Notch3 interface and identified a motif on Notch3 essential for stable binding. These findings provide molecular insights into platinum resistance in high-grade serous ovarian cancer and may support targeted therapy development. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-661108e elementor-widget elementor-widget-heading\" data-id=\"661108e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-644a229 elementor-widget elementor-widget-text-editor\" data-id=\"644a229\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">1: Romagnoli A, Rexha J, Perta N, Di Cristofano S, Borgognoni N, Venturini G, Pignotti F, <strong>Raimondo D<\/strong>, Borsello T, Di Marino D. Peptidomimetics design and characterization: Bridging experimental and computer-based approaches. Prog Mol Biol Transl Sci. 2025;212:279-327. doi: 10.1016\/bs.pmbts.2024.07.002. Epub 2024<br\/>Jul 25. PMID: 40122649.    <\/li><li>2: Cuollo L, Di Cristofano S, Sandomenico A, Iaccarino E, Oliver A, Zingoni A, Cippitelli M, Fionda C, Petillo S, Kosta A, Tassinari V, Petrucci MT, Fazio F, Ruvo M, Santoni A, <strong>Raimondo D<\/strong>, Soriani A. CD38 restrains the activity of extracellular cGAMP in a model of multiple myeloma. iScience. 2024 Apr 25;27(5):109814. doi: 10.1016\/j.isci.2024.109814. PMID: 38746669; PMCID: PMC11091702.<\/li><li>3: Turco EM, Giovenale AMG, Sireno L, Mazzoni M, Cammareri A, Marchioretti C, Goracci L, Di Veroli A, Marchesan E, D&#8217;Andrea D, Falconieri A, Torres B, Bernardini L, Magnifico MC, Paone A, Rinaldo S, Della Monica M, D&#8217;Arrigo S, Postorivo D, Nardone AM, Zampino G, Onesimo R, Leoni C, Caicci F, <strong>Raimondo D<\/strong>, Binda E, Trobiani L, De Jaco A, Tata AM, Ferrari D, Cutruzzol\u00e0 F, Mazzoccoli G, Ziviani E, Pennuto M, Vescovi AL, Rosati J. Retinoic acid-induced 1 gene haploinsufficiency alters lipid metabolism and causes autophagy defects in Smith-Magenis syndrome. Cell Death Dis. 2022 Nov 21;13(11):981. doi: 10.1038\/s41419-022-05410-7. PMID: 36411275; PMCID: PMC9678881.<\/li><li>4: Tornatore L, Capece D, D&#8217;Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, <strong>Raimondo D<\/strong>, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Preclinical toxicology and safety pharmacology of the first-in-class GADD45\u03b2\/MKK7 inhibitor and clinical candidate, DTP3. Toxicol Rep. 2019 Apr 19;6:369-379. doi: 10.1016\/j.toxrep.2019.04.006. PMID: 31080744; PMCID: PMC6502747.<\/li><li>5: Tornatore L, Sandomenico A, <strong>Raimondo D<\/strong>, Low C, Rocci A, Tralau-Stewart C, Capece D, D&#8217;Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G. Cancer- Selective Targeting of the NF-\u03baB Survival Pathway with GADD45\u03b2\/MKK7 Inhibitors.Cancer Cell. 2014 Dec 8;26(6):938. doi: 10.1016\/j.ccell.2014.11.021. Epub 2014 Dec 8. Cancer Cell. 2014 Oct 13;26(4):495-508. doi: 10.1016\/j.ccr.2014.07.027. PMID: 28898681; PMCID: PMC5629036.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Computational design of ultrashort peptides as protein surface binders\n <\/td>\n        <td>ISTITUTO PASTEUR ITALIA - FOND. CENCI BOLOGNETTI \n <\/td>\n        <td>40.000  <\/td>\n        <td>Marzo 2025\nFebbraio 2027\n <\/td>\n        <td>Principal Investigator<\/td>\n         <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Development of CES1 inhibitors to treat advanced colorectal carcinoma (CRC)\n<\/td>\n<td>SAPIENZA UNIVERSIT\u00c0 DI ROMA\n<\/td>\n<td>35.800 <\/td>\n<td>Gennaio 2025 Dicembre 2027\n<\/td>\n<td>Principal Investigator<\/td>\n         <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>AC-CURATE: Antiviral Compounds against Coronavirus Using pRotAcs TEchnology\n<\/td>\n<td>MINISTERO UNIVERSITA' RICERCA\n(MUR - PRIN 2022)\n\n<\/td>\n<td>41.700 <\/td>\n<td>Ottobre 2023\nSettembre 2025\n\n<\/td>\n<td>Principal Investigator of the Sapienza University research unit<\/td>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/domenico.raimondo.1\/bibliography\/public\/\">https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/domenico.raimondo.1\/bibliography\/public\/<\/a><\/span><\/p><p><strong>SCOPUS ID<\/strong>: 7004022334<\/p><p><strong>ORCID ID<\/strong>: <a href=\"https:\/\/www.scopus.com\/redirect.uri?url=https:\/\/orcid.org\/0000-0002-1780-7295&#038;authorId=7004022334&#038;origin=AuthorProfile&#038;orcId=0000-0002-1780-7295&#038;category=orcidLink\">0000-0002-1780-7295<\/a><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Bioinformatics, Computational Structural Biology, Biomedical macromolecules and pharmacologically active compounds, Drug design and optimization, Computational Immunology, Multiscale molecular simulations and modelling, Protein\u2013protein and protein\u2013ligand interactions<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Domenico Raimondo Associate Professor of Bioinformatics, Dept. Molecular Medicine \u2013 Sapienza University of Rome domenico.raimondo@uniroma1.it Academic Appointments: Since 2019: Associate Professor of Bioinformatics, Sapienza University of Rome 2018-2023: Junior Research Fellow, Sapienza School for Advanced Studies (SSAS) Since 2024: Board Member, PhD in \u201cBioinformatics and Computational Biology\u201d, Sapienza University of Rome Since 2017: Board Member, &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10639,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10640","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10640","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10640"}],"version-history":[{"count":2,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10640\/revisions"}],"predecessor-version":[{"id":10642,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10640\/revisions\/10642"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10639"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10640"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10640"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10640"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}