{"id":10645,"date":"2025-05-30T16:27:03","date_gmt":"2025-05-30T14:27:03","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/16\/rosa-alessandro\/"},"modified":"2026-07-16T14:04:46","modified_gmt":"2026-07-16T12:04:46","slug":"rosa-alessandro","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/16\/rosa-alessandro\/","title":{"rendered":"Rosa Alessandro"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10645\" class=\"elementor elementor-10645 elementor-8342\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Alessandro Rosa<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Alessandro-rosa.png\" class=\"attachment-full size-full wp-image-9937\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Alessandro-rosa.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Alessandro-rosa-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Alessandro-rosa-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Alessandro-rosa-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Alessandro-rosa-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor<\/h3><p class=\"elementor-image-box-description\">alessandro.rosa@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fc5ca08 elementor-widget elementor-widget-heading\" data-id=\"fc5ca08\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d13063d elementor-widget elementor-widget-text-editor\" data-id=\"d13063d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>2003-2007 Doctoral Student \/ Ph.D. program, Genetics and Molecular Biology, Sapienza University of Rome. <\/li><li>2007-2010 Postdoctoral associate. The Rockefeller University, New York, USA. Long term 2008 Human  <\/li><li>Frontier Science Program (HFSP) post-doctoral fellowship<\/li><li>2009-2010 Director of the Rockefeller University Stem Cell Derivation Core.<\/li><li>2011-2019 Assistant Professor (tenured in 2014), Sapienza University of Rome.<\/li><li>2019-present Associate Professor, Sapienza University of Rome.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f6de92 elementor-widget elementor-widget-heading\" data-id=\"8f6de92\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-08529e3 elementor-widget elementor-widget-text-editor\" data-id=\"08529e3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>2006. SIBBM (Italian Society of Biophysics and Molecular Biology) Award<\/li><li>2008. RNA Society 2008 poster award in the category \u201cGenetics and Development\u201d<\/li><li>2012. Bioeconomy Award \u201cFor the most innovative Italian intuitions of 2011 in the field of biomedical<br\/>sciences\u201d<\/li><li>2017. 1st Award at the business plan competition StartCup Lazio<\/li><li>2018. National Prize for Innovation Italy. Special award for best project for Equal Opportunities <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b59e315 elementor-widget elementor-widget-heading\" data-id=\"b59e315\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7ac3c2 elementor-widget elementor-widget-text-editor\" data-id=\"f7ac3c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>My overall research goal is elucidating molecular mechanisms that underlie neurodegenerative and neurodevelopmental diseases of the nervous system, with a particular focus on microRNAs and RNA-binding proteins. To achieve this goal, we take advantage of iPS cell-based in vitro models, including organoids and 3D bioprinted constructs. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b4cdf24 elementor-widget elementor-widget-heading\" data-id=\"b4cdf24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb254ad elementor-widget elementor-widget-text-editor\" data-id=\"fb254ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>During my PhD and post-doc, I studied microRNAs in hematopoietic differentiation and embryonic development. In 2005, we identified miR-223\u2019s role in granulopoiesis, demonstrating microRNAs&#8217; regulatory function in cell differentiation. We also revealed complex miRNA-transcription factor interactions in hematopoiesis. I later investigated the miR-430\/427\/302 family in X. laevis and human embryonic stem cells, showing their role in Nodal signaling and mesendodermal lineage promotion. Using iPSCs, we modeled amyotrophic lateral sclerosis (ALS), generating mutant lines and identifying transcriptomic and microRNA pathway changes. We discovered HuD as a key RNA-binding protein in ALS. Our lab pioneered 3D bioprinting of cortical constructs from human iPSC-derived neural cells and developed the first 3D brain organoids to model fragile X syndrome, advancing tissue engineering and regenerative medicine.      <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-19bf8f4 elementor-widget elementor-widget-heading\" data-id=\"19bf8f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72b8096 elementor-widget elementor-widget-text-editor\" data-id=\"72b8096\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Silvestri B, [\u2026] <strong>Rosa A<\/strong> (2024) HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models. Nat Commun 15: 9618  <\/li><li>Garone MG, Salerno D &#038; <strong>Rosa A<\/strong> (2023) Digital color-coded molecular barcoding reveals dysregulation of common FUS and FMRP targets in soma and neurites of ALS mutant motoneurons. Cell Death Discov 9: 33  <\/li><li>Brighi C, [\u2026] <strong>Rosa A*<\/strong> &#038; Di Angelantonio S* (2021) Novel fragile X syndrome 2D and 3D brain models based on human isogenic FMRP-KO iPSCs. Cell Death Dis 12: 498. *Co-last authors  <\/li><li>Garone MG, [\u2026] <strong>Rosa A<\/strong> (2021) ALS-related FUS mutations alter axon growth in motoneurons and affect HuD\/ELAVL4 and FMRP activity. Commun Biol 4: 1025  <\/li><li>De Santis R [\u2026] <strong>Rosa A<\/strong> (2019) Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis. Cell Rep 27: 3818-3831.e5  <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>HSPB3: a promising candidate for the maintenance of the neuromuscular system\n<\/td>\n<td>Muscular Dystrophy Association (MUR)\n<\/td>\n<td>140.000 <\/td>\n<td>1\/9\/2022 -31\/8\/2025\n<\/td> <td>Co-PI (5 % of time)<\/td><\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>CN3_Spoke_3 - Sviluppo di terapia genica e farmaci con tecnologia a RNA\n<\/td>\n<td>MUR - PNRR\n<\/td>\n<td>186.025 <\/td>\n<td>1\/11\/2022 -28\/2\/2026\n<\/td>\n<td>Co-PI (25 % of time) <\/td> \n        <\/tr>\n        <td>Unraveling the role of SUMO2\/3 as a modifier of TDP-43 solubility: a new therapeutic avenue for ALS\n <\/td>\n        <td>AriSLA\n <\/td>\n        <td>35.200  <\/td>\n        <td>1\/3\/2023 -28\/2\/2027\n <\/td> <td>Co-PI (5 % of time)<\/td><\/tr>\n <td>HSPB3: understanding its role in the pathophysiology of the neuromuscular system and testing its druggability for future therapeutic purposes\n<\/td>\n<td>MUR - PRIN 2022\n<\/td>\n<td>87.737 <\/td>\n<td>18\/10\/2023 -28\/2\/2026\n<\/td> <td>Co-PI (15 % of time)<\/td>\n <\/tr>\n <td>Generation and characterization of a new in vitro model for GNAO1 encephalopathy based on human iPS cells and cortical organoids\n<\/td>\n<td>MUR - PRIN 2022 PNRR\n<\/td>\n<td>120.610 <\/td>\n<td>1\/12\/2023 -28\/2\/2026\n<\/td> <td>PI (15 % of time)<\/td>\n <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>StressHUD, Investigating the Mechanisms Underlying Oxidative Stress-Induced HuD Expression in Sporadic ALS\n<\/td>\n<td>AriSLA\n<\/td>\n<td>60.000 <\/td>\n<td>1\/5\/2025 \u2013 30\/4\/2026\n<\/td> <td>PI (10 % of time)<\/td><\/tr>\n  <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Generation and characterization of neuromuscular organoids as model systems for amyotrophic lateral sclerosis\n <\/td>\n <td>ISTITUTO PASTEUR ITALIA Fondazione Cenci Bolognetti\n <\/td>\n <td>40.000 <\/td>\n <td>1\/3\/2025 \u2013 28\/2\/2027\n <\/td> <td>PI (10 % of time)<\/td><\/tr>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1656MU5dzteAg\/bibliography\/public\/\">https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1656MU5dzteAg\/bibliography\/public\/<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>amyotrophic lateral sclerosis; RNA-binding protein; FUS; HuD; ELAVL4; organoids; GNAO1; induced pluripotent stem cells; microRNA.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Alessandro Rosa Associate Professor alessandro.rosa@uniroma1.it Academic Appointments 2003-2007 Doctoral Student \/ Ph.D. program, Genetics and Molecular Biology, Sapienza University of Rome. 2007-2010 Postdoctoral associate. The Rockefeller University, New York, USA. Long term 2008 Human Frontier Science Program (HFSP) post-doctoral fellowship 2009-2010 Director of the Rockefeller University Stem Cell Derivation Core. 2011-2019 Assistant Professor (tenured in &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10644,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10645","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10645","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10645"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10645\/revisions"}],"predecessor-version":[{"id":10646,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10645\/revisions\/10646"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10644"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10645"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10645"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10645"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}