{"id":10652,"date":"2025-05-30T15:11:48","date_gmt":"2025-05-30T13:11:48","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/15\/nocella-cristina\/"},"modified":"2026-07-16T14:07:29","modified_gmt":"2026-07-16T12:07:29","slug":"nocella-cristina","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/15\/nocella-cristina\/","title":{"rendered":"Nocella Cristina"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10652\" class=\"elementor elementor-10652 elementor-8327\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Cristina Nocella<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Nocella.png\" class=\"attachment-full size-full wp-image-10650\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Nocella.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Nocella-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Nocella-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Nocella-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Nocella-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">RTDB<\/h3><p class=\"elementor-image-box-description\">cristina.nocella@uniroma1.it <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eaec3bc elementor-widget elementor-widget-heading\" data-id=\"eaec3bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-959efb8 elementor-widget elementor-widget-text-editor\" data-id=\"959efb8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>2022-In progress: RTDB, Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome<\/li><li>2019-2022: RTDA, Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome<\/li><li>2013-2016: PhD Degree in \u201cImmunological, Haematological and Rheumatological Sciences\u201d, Sapienza University of Rome<\/li><li>2011-2014: Research Fellow, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome<\/li><li>2007-2009: Master Degree in \u201cBiology applied to biomedical research\u201d, magna cum laude, Sapienza University of Rome<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4650f91 elementor-widget elementor-widget-heading\" data-id=\"4650f91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9874c9 elementor-widget elementor-widget-text-editor\" data-id=\"e9874c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Holder of two patents:<\/p><ul><li>1) European patent: <a href=\"https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2019111142\">https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2019111142<\/a><\/li><li>2) National patent: n\u00b0 102017000064897.<\/li><li>&#8211; EDITORIAL BOARD MEMBERSHIPS. Antioxidants; Oxidative Medicine and Cellular Longevity <\/li><li>&#8211; Member of the Italian Society of Pathology and Translational Medicine (SIPMeT)<\/li><li>&#8211; Member of the Italian Society for the Study of Haemostasis and Thrombosis (SISET)<\/li><li>&#8211; Eligible to be appointed as associate professor for the Settore Concorsuale 06\/N1 from 22\/06\/2020 to 22\/06\/2029<\/li><\/ul><p> <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-15fbc4e elementor-widget elementor-widget-heading\" data-id=\"15fbc4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b18ae5b elementor-widget elementor-widget-text-editor\" data-id=\"b18ae5b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">My scientific interest is mainly in studying the mechanisms of platelet activation, which plays a role in the onset of cardiovascular disease. Among mechanisms that elicit platelet activation, oxidative stress plays a major role in favoring platelet hyperactivity. Indeed, upon stimulation by physiological agonists, human platelets generate and release several types of reactive oxygen species (ROS) by NOX2 activation. More recently, I studied other mechanisms of platelet activation such as during an inflammatory response. In these pathological conditions, platelet activation could be mediated by different promoting factors such as LPS. Finally, my interest is in the functional modulation of these pathways through pharmacological or nutraceutical approaches.     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-95ff01e elementor-widget elementor-widget-heading\" data-id=\"95ff01e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science \n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b63c05a elementor-widget elementor-widget-text-editor\" data-id=\"b63c05a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\"><b>Mechanism of platelet activation:<\/b> LPS, at a concentration similar to that we found in human circulation, could trigger platelet aggregation and activation. LPS promotes thrombus growth by the amplification and propagation of platelet aggregation therefore the reduction of circulating LPS levels could represent a strategy potentially useful for reducing the thrombotic process. <\/p><p class=\"p1\"><b>NOX2-mediated oxidative stress and NOX2 regulation:<\/b> metalloproteinase 2 (MMP2), a zinc- and calcium-dependent endopeptidase, modulates oxidative stress by regulating NOX2 activity in platelets and polymorphonuclear cells.<\/p><p class=\"p1\"><b>Antioxidant treatment and nutraceutical approach:<\/b> a high adherence to the Mediterranean diet, specific components of extra-virgin olive oil (EVOO) such as oleuropein, and a mix of polyphenols (catechin and epicatechin) and trehalose, reduce the impact of risk factors on the onset of cardiovascular disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e6c222 elementor-widget elementor-widget-heading\" data-id=\"9e6c222\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a74e21 elementor-widget elementor-widget-text-editor\" data-id=\"2a74e21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">1: <b>Nocella C<\/b> et al. Dark Chocolate Intake Positively Modulates Gut Permeability in Elite Football Athletes: A Randomized Controlled Study. Nutrients. 2023;15:4203.   <\/li><li class=\"p1\">2: Violi F, Cammisotto V, Bartimoccia S, Pignatelli P, Carnevale R, <b>Nocella C<\/b>. Gut-derived low-grade endotoxaemia, atherothrombosis and cardiovascular disease. Nat Rev Cardiol. 2023;20(1):24-37.   <\/li><li class=\"p1\">3: <b>Nocella C<\/b> et al. Structure, Activation, and Regulation of NOX2: At the Crossroad between the Innate Immunity and Oxidative Stress-Mediated Pathologies. Antioxidants (Basel). 2023;12(2):429.   <\/li><li class=\"p1\">4. <b>Nocella C<\/b>, et al. A novel role of MMP2 in regulating platelet NOX2 activation. Free Radic Biol Med. 2020;152:355-362.  <\/li><li class=\"p1\"><b>Nocella C<\/b>, et al. Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production. Thromb Haemost. 2017;117:1558-1570.   <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>The role of platelet NOX2-mediated oxidative stress and autophagy in Alzheimer's disease: new therapeutic strategies\n<\/td>\n<td>Istituto\nPasteur\n<\/td>\n<td>40.000 <\/td>\n<td>01\/03\/2025-28\/02\/2027\n<\/td>\n<td>PI (100 % of time)<\/td>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=cristina+nocella&#038;sort=date&#038;size=200\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=cristina+nocella&#038;sort=date&#038;size=200<\/a><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Platelet activation; Gut-derived LPS; NOX2; Oxidative stress; Antioxidants.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Cristina Nocella RTDB cristina.nocella@uniroma1.it Academic Appointments: 2022-In progress: RTDB, Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome 2019-2022: RTDA, Department of Clinical, Internal, Anaesthesiology and Cardiovascular Sciences, Sapienza University of Rome 2013-2016: PhD Degree in \u201cImmunological, Haematological and Rheumatological Sciences\u201d, Sapienza University of Rome 2011-2014: Research Fellow, Department of Internal Medicine &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10651,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10652","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10652","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10652"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10652\/revisions"}],"predecessor-version":[{"id":10653,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10652\/revisions\/10653"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10651"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10652"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10652"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10652"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}