{"id":10655,"date":"2025-05-30T13:19:08","date_gmt":"2025-05-30T11:19:08","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/13\/tuosto-loretta\/"},"modified":"2026-07-16T14:08:39","modified_gmt":"2026-07-16T12:08:39","slug":"tuosto-loretta","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/13\/tuosto-loretta\/","title":{"rendered":"Tuosto Loretta"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10655\" class=\"elementor elementor-10655 elementor-8320\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Loretta Tuosto<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Tuosto.png\" class=\"attachment-full size-full wp-image-9976\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Tuosto.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Tuosto-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Tuosto-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Tuosto-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Tuosto-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Associate Professor<\/h3><p class=\"elementor-image-box-description\">loretta.tuosto@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1494714 elementor-widget elementor-widget-heading\" data-id=\"1494714\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ae80bd elementor-widget elementor-widget-text-editor\" data-id=\"4ae80bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>1994-1996 Fellowship for the research on AIDS, by &#8220;Istituto Superiore di Sanit\u00e0&#8221;, Molecular Immunology Unit Institut Pasteur, Paris France<\/li><li>1996-1997 Fellowship by &#8220;Foundation pour la Recherche Medical&#8221; Molecular Immunology Unit Institut Pasteur, Paris France<\/li><li>1997-1999 Fellowship by Istituto Pasteur- Fondazione Cenci Bolognetti, Dept. Cell. Biol. and Develop., Sapienza University of Rome<\/li><li>1999-2004 Research contract, Dept. Cell. Biol. and Develop., Sapienza University of Rome<\/li><li>2004-2012 Assistant Professor, Faculty of SMFN, Sapienza University of Rome<\/li><li>2012-present Associate Professor of Immunology, Sapienza University of Rome<\/li><li>20225 Call as Full Professor, Sapienza University of Rome<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ffffc32 elementor-widget elementor-widget-heading\" data-id=\"ffffc32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4a792c elementor-widget elementor-widget-text-editor\" data-id=\"a4a792c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>1998 1st Prize PBI (GCI) for research activtity<\/li><li>2000 1st Prize Mascia Brunelli, Associazione Italiana Colture Cellulari (ONLUS-AICC, 2000)<\/li><li>2004-present Member of the Societ\u00e0 Italiana d\u2019Immunologia, Immunologia Clinica ed Allergologia (SIICA)<\/li><li>2010-present Member of the European Association for Cancer Research (EACR)<\/li><li>2016-present Associate Editor of Frontiers in Immunology, section \u201cT cell Biology\u201d<\/li><li>2018-present F1000 Faculty member\/H1 connect<\/li><li>2020 Vigevani Research Project Prize 2020<\/li><li>2022-present Associate Editor of Cells, MDPI Journals<\/li><li>2024-present Associate Editor of Frontiers in Molecular Biosciences, section \u201cMolecular Diagnostics and Therapeutics\u201d<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9660d16 elementor-widget elementor-widget-heading\" data-id=\"9660d16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9186223 elementor-widget elementor-widget-text-editor\" data-id=\"9186223\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Our research activity is focused in the fields of cellular and molecular immunology and oncology. In particular, we evidenced that the engagement of CD28 costimulatory molecule activates in primary T lymphocytes a non-canonical NF-<span class=\"s1\">\u03ba<\/span>B2-like cascade leading to the selective recruitment of RelA\/p52 and RelA\/RelA dimers on the promoter of several NF-<span class=\"s1\">\u03ba<\/span>B target genes including survival and inflammatory genes. We also characterized the role of CD28 in the regulation of the metabolic and inflammatory processes in Multiple Sclerosis (MS), highlighting an important contribution of class 1A PI3K associated with CD28 in the reprogramming of the metabolic processes that maintain\/amplify the inflammatory phenotype of peripheral T lymphocytes.  <\/p><p class=\"p1\">Actually, we are working on the characterization of the role of CD28 in the inflammatory response to bacterial superantigens and on novel immunotherapeutic strategies for ovarian cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cee675f elementor-widget elementor-widget-heading\" data-id=\"cee675f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-aab6229 elementor-widget elementor-widget-text-editor\" data-id=\"aab6229\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Our research activity has been focused at characterizing the role of p53 and p73 oncosuppressors in the acquisition of resistance to apoptosis by tumour cells. These studies contributed to the identification of a new tumour-associated mutant of p53 (K351N) involved in the acquisition of resistance to apoptosis in ovarian cancer. <\/p><p class=\"p1\">We also contributed at characterizing the mechanisms and molecules regulating the inflammatory signals elicited by human CD28 costimulatory molecule in primary T lymphocytes. We were among the first to identify at a cellular and molecular level of distinct signalling abilities between human and mouse CD28, thus emphasizing the essential need to pay attention to molecular details when transferring results from preclinical models to the bedside. <\/p><p class=\"p1\">We also clarify the pivotal role of membrane phospholipid kinases (PIP5K, PIP4K and class 1A PI3K), in the regulation of the TCR and CD28 downstream signaling functions in T lymphocytes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c9c8bee elementor-widget elementor-widget-heading\" data-id=\"c9c8bee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c6d8092 elementor-widget elementor-widget-text-editor\" data-id=\"c6d8092\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nun\u00e8s JA, Borroto A, Alarcon B, Screpanti I, <strong>Tuosto L<\/strong>. A non-conserved amino acid variant regulates differential signalling between human and mouse CD28. Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038\/s41467-018-03385-8.    <\/li><li class=\"p1\"><strong>Tuosto L<\/strong>, Capuano C, Muscolini M, Santoni A, Galandrini R. The multifaceted role of PIP2 in leukocyte biology. Cell Mol Life Sci. 2015 Dec;72(23):4461-74. doi: 10.1007\/s00018-015-2013-0.   <\/li><li class=\"p1\">Cianfrocca R, Muscolini M, Marzano V, Annibaldi A, Marinari B, Levrero M, Costanzo A, <strong>Tuosto L<\/strong>. RelA\/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells. Cell Death Differ. 2008 Feb;15(2):354-63. doi: 10.1038\/sj.cdd.4402264.<\/li><li class=\"p1\">Tavano R, Contento RL, Baranda SJ, Soligo M, <strong>Tuosto L<\/strong>, Manes S, Viola A. CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse. Nat Cell Biol. 2006 Nov;8(11):1270-6. doi: 10.1038\/ncb1492.  <\/li><li class=\"p1\">Marinari B, Costanzo A, Marzano V, Piccolella E, <strong>Tuosto L<\/strong>. CD28 delivers a unique signal leading to the selective recruitment of RelA and p52 NF-kappaB subunits on IL-8 and Bcl-xL gene promoters. Proc Natl Acad Sci USA. 2004 Apr 20;101(16):6098-103. doi: 10.1073\/pnas.0308688101.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Improving ovarian cancer immunotherapy by the combination of Discoidin Domain Receptor 2 blockade and bispecific antibodies\ntargeting CD28 and tumour-associated antigens\n<\/td>\n<td>PRIN 2022 PNRR <\/td>\n<td>92.035 <\/td>\n<td>01.12.2023-30.11.2025\n<\/td>\n<td>PI (30% of time)<\/td>\n    <\/tr>\n        <tr class=\"ricercatori-table-row\">\n        <td>Dissecting how microenvironment remodelled by tumor and stromal cells facilitate ovarian cancer metastasis: interaction between integrins and microbiome\n<\/td>\n<td>PRIN 2022 <\/td>\n<td>54.375 <\/td>\n<td>04.02.2025-03.02.2027\n<\/td>\n<td>PI (20% of time)\n<\/td>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/loretta.tuosto.1\/bibliography\/public\/\">https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/loretta.tuosto.1\/bibliography\/public\/<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>T cells; CD28; Inflammation; Multiple Sclerosis; Staphylococcal superantigens; Cancer immunotherapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Loretta Tuosto Associate Professor loretta.tuosto@uniroma1.it Academic Appointments 1994-1996 Fellowship for the research on AIDS, by &#8220;Istituto Superiore di Sanit\u00e0&#8221;, Molecular Immunology Unit Institut Pasteur, Paris France 1996-1997 Fellowship by &#8220;Foundation pour la Recherche Medical&#8221; Molecular Immunology Unit Institut Pasteur, Paris France 1997-1999 Fellowship by Istituto Pasteur- Fondazione Cenci Bolognetti, Dept. Cell. Biol. and Develop., Sapienza &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10654,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10655","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10655","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10655"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10655\/revisions"}],"predecessor-version":[{"id":10656,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10655\/revisions\/10656"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10654"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10655"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10655"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10655"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}