{"id":10677,"date":"2025-05-28T16:30:26","date_gmt":"2025-05-28T14:30:26","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/16\/perfetto-livia\/"},"modified":"2026-07-16T14:20:37","modified_gmt":"2026-07-16T12:20:37","slug":"perfetto-livia","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/16\/perfetto-livia\/","title":{"rendered":"Perfetto Livia"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10677\" class=\"elementor elementor-10677 elementor-8225\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Livia Perfetto<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Livia-Perfetto.png\" class=\"attachment-full size-full wp-image-10675\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Livia-Perfetto.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Livia-Perfetto-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Livia-Perfetto-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Livia-Perfetto-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/Livia-Perfetto-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Researcher (rtdB) and Assistant Professor at University of Rome, La Sapienza, Italy<\/h3><p class=\"elementor-image-box-description\">livia.perfetto@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a40740d elementor-widget elementor-widget-heading\" data-id=\"a40740d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fdeec24 elementor-widget elementor-widget-text-editor\" data-id=\"fdeec24\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2022-Present, University of Rome La Sapienza, Rome (Italy), Researcher and Assistant Professor<\/li><li class=\"p1\">2021-Present, University of Cambridge, Visitor Scientist<\/li><li class=\"p1\">2020-2022, Fondazione Human Technopole, Milan (Italy), Scientific Consultant and SIGNOR project coordinator<\/li><li class=\"p1\">2020-2022, European Bioinformatic Institute (EMBL-EBI), Cambridge (UK), Visitor Scientist<\/li><li class=\"p1\">2017-2020, European Bioinformatic Institute (EMBL-EBI), Cambridge (UK), Staff member (senior curator and bioinformatician)<\/li><li class=\"p1\">2016-2017, University of Rome \u2018Tor Vergata\u2019, Rome (Italy), Post-doc (AIRC personal fellowship GRANT)<\/li><li class=\"p1\">2014-2016, University of Rome \u2018Tor Vergata\u2019 Rome (Italy), Post-doc<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-edfe40e elementor-widget elementor-widget-heading\" data-id=\"edfe40e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8574fcd elementor-widget elementor-widget-text-editor\" data-id=\"8574fcd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">2025. Awarded an Istituto Pasteur Cenci Bolognetti under 40 grant.<\/li><li class=\"p1\">2023. Awarded a My First AIRC grant, AIRC.<\/li><li class=\"p1\">2023. Awarded a PRIN PNRR 2022 grant, NextGenerationEU<\/li><li class=\"p1\">2022. Awarded a University of Rome, La Sapienza Seed GRANT<\/li><li class=\"p1\">2016. Awarded a COST action grant (within the COST Action CA15205) to organize the GREEKC Action Planning Meeting, Core Group Meeting.<\/li><li class=\"p1\">2015. Awarded a triennial fellowship Starwood Hotels &#038; Resorts (AIRC grant) selected on a peer-review basis<\/li><li class=\"p1\">2011. Awarded a FEBS Youth Travel grant<\/li><li class=\"p1\">2010, Awarded 5000 \u20ac Special Prize \u2018Sebastiano and Rita Raeli\u2019 as best student of the year.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d7e2a9 elementor-widget elementor-widget-heading\" data-id=\"4d7e2a9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76ab776 elementor-widget elementor-widget-text-editor\" data-id=\"76ab776\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">From the beginning of my research I have focused on Biological Networks and on the functional insights we can gain from the analysis of physical and causal relationships between proteins. I have contributed to this general goal by looking at it from several angles. Indeed at the center of my research interests are networks of causal interactions which can provide the structure to integrate multi-omics datasets by building context-specific models that are mechanistic (can provide understanding) or predictive (can generate novel hypotheses).  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e5ae58 elementor-widget elementor-widget-heading\" data-id=\"5e5ae58\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1eacaf elementor-widget elementor-widget-text-editor\" data-id=\"c1eacaf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">During my PhD, I worked toward the development of <b>SIGNOR,<\/b> a publicly available resource of causal interactions, pathways and phenotypes embedded in the cell interactome. Since its establishment in 2015, SIGNOR has stably grown in terms data content, citations (&gt; 250) and international collaborations. Over the years I demonstrated that data in SIGNOR could be exploited to understand the dynamics of the molecular mechanisms of diseases and to build tools for patient stratification and diagnosis in personalized medicine. I supervised the implementation of tools such as <b><i>SignalingProfiler and PatientProfiler<\/i><\/b>, computational strategies for <b>multi-omics integration<\/b> that combine MS-based phosphoproteomic and transcriptomic data with causal networks to derive context-specific models of cancer or drug response. In addition, I also developed <b>ProxPath<\/b>, a network-based approach contributes to identifying phenotypes that are &#8216;significantly close&#8217; to a protein hit list. In summary, I explored the mechanistic links connecting the suggested gene-phenotype relations.     <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6f68f6 elementor-widget elementor-widget-heading\" data-id=\"e6f68f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5de55d3 elementor-widget elementor-widget-text-editor\" data-id=\"5de55d3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"p1\">Lombardi L., Di Rocco L., Meo E., Venafra V., Di Nisio E., Perticaroli V., Nicolaeasa L.M., Cencioni C., Spallotta F., Negri R., Sacco F., <b>Perfetto L.*<\/b>. PatientProfiler: A network-based approach to personalized medicine. BiorXiv 2025  <\/li><li class=\"p1\">Venafra V, Sacco F<b>, Perfetto L*<\/b>. SignalingProfiler 2.0 a network-based approach to bridge multi-omics data to phenotypic hallmarks. NPJ Syst Biol Appl. 2024 Aug 23;10(1):95. doi: 10.1038\/s41540-024-00417-6.    <\/li><li class=\"p1\">Latini S, Venafra V, Massacci G, Bica V, Graziosi S, Pugliese GM, Iannuccelli M, Frioni F, Minnella G, Marra JD, Chiusolo P, Pepe G, Helmer Citterich M, Mougiakakos D, B\u00f6ttcher M, Fischer T, <strong>Perfetto L<\/strong>*, Sacco F. Unveiling the signaling network of FLT3-ITD AML improves drug sensitivity prediction. Elife. 2024 Apr 2;12:RP90532. doi: 10.7554\/eLife.90532.   <\/li><li class=\"p1\">Iannuccelli M, Vitriolo A, Licata L, Lo Surdo P, Contino S, Cheroni C, Capocefalo D, Castagnoli L, Testa G, Cesareni G, <strong>Perfetto L*<\/strong>. Curation of causal interactions mediated by genes associated with autism accelerates the understanding of gene-phenotype relationships underlying neurodevelopmental disorders. Mol Psychiatry. 2024 Jan;29(1):186-196. doi: 10.1038\/s41380-023-02317-3. Epub 2023 Dec 15. Erratum in: Mol Psychiatry. 2024 Jan;29(1):197. doi: 10.1038\/s41380-024-02432-9.        <\/li><li class=\"p1\"><strong>Perfetto L<\/strong>, Briganti L, Calderone A, Cerquone Perpetuini A, Iannuccelli M, Langone F, Licata L, Marinkovic M, Mattioni A, Pavlidou T, Peluso D, Petrilli LL, Pirr\u00f2 S, Posca D, Santonico E, Silvestri A, Spada F, Castagnoli L, Cesareni G. SIGNOR: a database of causal relationships between biological entities. Nucleic Acids Res. 2016 Jan 4;44(D1):D548-54. doi: 10.1093\/nar\/gkv1048. Epub 2015 Oct 13.   <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Building SigMod, a web Resource for PTM browsing and functional visualization <\/td>\n<td>Istituto Pasteur Italia, Fondazione Cenci Bolognetti <\/td>\n<td>40.000 <\/td>\n<td>1\/3\/2025 \u2013 \n28\/2\/2027\n<\/td>\n<td>PI<\/td>\n    <\/tr>\n        <tr class=\"ricercatori-table-row\">\n        <td>Modelling cell communication in Pancreatic Cancer: A Systems Biology Approach to Personalized Treatments\n<\/td>\n<td>AIRC <\/td>\n<td>375.452 <\/td>\n<td>1\/1\/2024 \u2013\n31\/12\/2029\n<\/td>\n<td>PI (50% of time)<\/td>\n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>A systems-based approach toward personalised therapeutic strategies in Pancreatic ductal adenocarcinoma\n<\/td>\n<td>NextGenerationEU <\/td>\n<td>229.498 <\/td>\n<td>1\/12\/2023 \u2013\n30\/11\/2025\n<\/td>\n<td>PI (25% of time)<\/td>\n    <\/tr>\n    \n    \n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=livia+perfetto\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=livia+perfetto<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Bioinformatics, systems biology, network modelling, cancer mechanisms, database.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Livia Perfetto Researcher (rtdB) and Assistant Professor at University of Rome, La Sapienza, Italy livia.perfetto@uniroma1.it Academic Appointments: 2022-Present, University of Rome La Sapienza, Rome (Italy), Researcher and Assistant Professor 2021-Present, University of Cambridge, Visitor Scientist 2020-2022, Fondazione Human Technopole, Milan (Italy), Scientific Consultant and SIGNOR project coordinator 2020-2022, European Bioinformatic Institute (EMBL-EBI), Cambridge (UK), Visitor &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10676,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10677","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10677"}],"version-history":[{"count":2,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10677\/revisions"}],"predecessor-version":[{"id":10680,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10677\/revisions\/10680"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10676"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10677"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10677"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10677"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}