{"id":10684,"date":"2025-05-27T18:40:29","date_gmt":"2025-05-27T16:40:29","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2025\/18\/de-falco-elena\/"},"modified":"2026-07-16T14:22:52","modified_gmt":"2026-07-16T12:22:52","slug":"de-falco-elena","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2025\/18\/de-falco-elena\/","title":{"rendered":"De Falco Elena"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10684\" class=\"elementor elementor-10684 elementor-8204\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3b2f5c72 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b2f5c72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-25333428\" data-id=\"25333428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b44d30a elementor-widget elementor-widget-spacer\" data-id=\"b44d30a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-90de0e1 elementor-widget elementor-widget-heading\" data-id=\"90de0e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Elena De Falco<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38160b2 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"38160b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/elena-de-falco.png\" class=\"attachment-full size-full wp-image-10682\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/elena-de-falco.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/elena-de-falco-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/elena-de-falco-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/elena-de-falco-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2025\/05\/elena-de-falco-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Biographical Sketch<\/h3><p class=\"elementor-image-box-description\">elena.defalco@uniroma1.it <\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc9085 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc9085\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e7ebeae\" data-id=\"e7ebeae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5fc1f9f elementor-widget elementor-widget-heading\" data-id=\"5fc1f9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb9eeec elementor-widget elementor-widget-text-editor\" data-id=\"bb9eeec\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"s11\"><span class=\"s4\">1. <\/span><span class=\"s8\">Associate Professor (06\/A2 MED\/05)- Full Time University of Rome \u201cSapienza\u201d, Faculty of Pharmacy and Medicine Department of Medical-Surgical Sciences and Biotechnologies, <\/span><span class=\"s8\">C.so della Repubblica 79, 04100 Latina, Italy<\/span><\/li><li class=\"s11\"><span class=\"s4\">2. <\/span><span class=\"s8\">Head of Pathologist, Clinical Pathology Unit (UOC), Sapienza University of Rome <\/span><span class=\"s8\">Istituto Chirurgico Ortopedico Traumatologico ICOT Latina, Italy<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a2984ef elementor-widget elementor-widget-heading\" data-id=\"a2984ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-22a3886 elementor-widget elementor-widget-text-editor\" data-id=\"22a3886\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"s14\"><span class=\"s4\">1. <\/span><span class=\"s4\">Erasmus and International Credit Mobility at Department of Pharmacology and Toxicology Ernest Mario School of Pharmacy, Rutgers at Rutgers University, USA<\/span><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42ed44c elementor-widget elementor-widget-heading\" data-id=\"42ed44c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-727aa5e elementor-widget elementor-widget-text-editor\" data-id=\"727aa5e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"s15\">Professor Elena De Falco&#8217;s research focuses on the regenerative and pathological roles of <\/span><span class=\"s15\">the stromal fraction of both cardiac and adipose origin<\/span><span class=\"s15\">. She has demonstrated their plasticity<\/span><span class=\"s15\">, the<\/span><span class=\"s15\"> potential to differentiate into cardiovascular cells<\/span><span class=\"s15\"> and <\/span><span class=\"s15\">how they <\/span><span class=\"s15\">control<\/span><span class=\"s15\"> car<\/span><span class=\"s15\">diac fibrosis<\/span><span class=\"s15\">, <\/span><span class=\"s15\">including <\/span><span class=\"s15\">by the mean <\/span><span class=\"s15\">of <\/span><span class=\"s15\">human platelet lysate-based product<\/span><span class=\"s15\">s<\/span><span class=\"s15\"> for cardiovascular repair<\/span><span class=\"s15\">. Her work also explores how oxidative stress affects endothelial function and vascular aging<\/span> <span class=\"s15\"> by epigenetic mechanisms<\/span><span class=\"s15\"> and the link to <\/span><span class=\"s15\">diabetes<\/span> <span class=\"s15\">and the beneficial role of dietary antioxidants. Additionally, she revealed that <\/span> <span class=\"s15\">the stromal fraction <\/span><span class=\"s15\">from cancer patients can mimic tumor-supporting <\/span><span class=\"s15\">environments and<\/span><span class=\"s15\"> highlighted <\/span><span class=\"s15\">escaping mechanisms in breast cancer<\/span><span class=\"s15\">,  <\/span><span class=\"s15\">the development of innovative therapeutic strategies<\/span><span class=\"s15\"> such as the <\/span><span class=\"s15\">thermal physics <\/span><span class=\"s15\">and molecular mechanisms underlying <\/span><span class=\"s15\">cancer progression mediated by <\/span><span class=\"s15\">tumor <\/span><span class=\"s15\">microenvironment.<\/span> <span class=\"s15\">Recently, <\/span><span class=\"s15\">s<\/span><span class=\"s15\">he is investigating the combination of drugs targeting epigenetic mechanisms<\/span><span class=\"s15\"> (i.e. <\/span><span class=\"s15\">allosteric activators<\/span><span class=\"s15\"> of sirtuins)<\/span><span class=\"s15\"> with cardiovascular drugs<\/span><span class=\"s15\">,<\/span><span class=\"s15\"> as well as the potential use of <\/span><span class=\"s15\">anthelmintics<\/span><span class=\"s15\"> for cancer treatment<\/span><span class=\"s15\">.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3b54367 elementor-widget elementor-widget-heading\" data-id=\"3b54367\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">5 Selected publications:\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1b9413d elementor-widget elementor-widget-text-editor\" data-id=\"1b9413d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li class=\"s17\"><span class=\"s4\">1. <\/span><span class=\"s15\">Remote adipose tissue-derived stromal cells of patients with lung adenocarcinoma generate a similar malignant microenvironment of the lung stromal counterpart. <strong>De Falco E<\/strong>., Bordin S., Menna C, Dhori X, Picchio V., Cozzolino C., De Marinis E, Floris E., Giorgiano NM, Rosa P., Rendina EA., Ibrahim M., Calogero A. Journal of Oncology vol. 2023, Article ID 1011063, 15 pages, 2023. doi.org\/10.1155\/2023\/1011063<\/span><\/li><li><span class=\"s4\">2. <\/span><span class=\"s15\">Bordin A, Chiriv\u00ec M, Francesca Pagano F, Milan M, Iuliano M, Scaccia E, Fortunato O, Mangino G, Dhori X, De Marinis E, D\u2019Amico A, Miglietta S, Picchio V, Rizzi R, Romeo G, Pulcinelli F, Chimenti I, Frati G, <strong>De Falco E<\/strong>. Human platelet lysate derived extracellular vesicles enhance angiogenesis through miR-126. Cell proliferation Cell Prolif. 2022 Aug 9:e13312. doi: 10.1111\/cpr.13312.<\/span><\/li><li><span class=\"s4\">3. <\/span><span class=\"s15\">Margariti A, Zampetaki A, Xiao Q, Zhou B, Karamariti E, Martin D, Yin X, Mayr M, Li H, Zhang Z, <strong>De Falco E<\/strong>, Hu Y, Cockerill G, Xu Q, Zeng L. Histone Deacetylase 7 Controls Endothelial Cell Growth through Stabilization of \u03b2-Catenin. Circ Res. 2010 Apr 16;106(7):1202-11. Doi: 10.1161\/CIRCRESAHA.109.213165.<\/span><\/li><li><span class=\"s4\">4. <\/span><span class=\"s15\"><strong>De Falco E<\/strong>, Porcelli D, Torella AR, Straino S, Iachininoto MG, Orlandi A, Truffa S, Biglioli P, Napolitano M, Capogrossi MC, Pesce M. SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitors cells. Blood 2004;104(12):3472-82.<\/span><\/li><li><span class=\"s4\">5. <\/span><span class=\"s15\"><strong>De Falco E<\/strong>, Avitabile D, Totta P, Straino S, Spallotta F, Cencioni C, Torella AR, Rizzi R, Porcelli D, Zacheo A, Di Vito L, Pompilio G, Napolitano M, Melillo G, Capogrossi MC, Pesce M. Altered SDF-1 mediated differentiation of bone marrow-derived endothelial progenitor cells in diabetes mellitus. J Cell Mol Med. 2009 Sep;13(9B):3405-14. Doi: 10.1111\/j.1582-4934.2009.00655.x<\/span><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ed18a22 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ed18a22\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-51be655\" data-id=\"51be655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f77c831 elementor-widget elementor-widget-heading\" data-id=\"f77c831\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e16126 elementor-widget elementor-widget-html\" data-id=\"7e16126\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title <\/td>\n        <td>Funding source <\/td>\n        <td>Amount (Euros) <\/td>\n        <td>Period <\/td>\n        <td>Role of the PI <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>New molecular mechanisms underlying BRAFi\/MEKi-induced cardiotoxicity: a multidisciplinary research project from bench to bedside <\/td>\n<td>Sapienza University of Rome <\/td>\n<td>70.020 <\/td>\n<td>2024-2026 <\/td>\n<td>As Co-PI (10%) <\/td> \n    <\/tr>\n        <tr class=\"ricercatori-table-row\">\n        <td>Advanced and automated innovation labs for diagnostic and therapeutic biopharma solution. Linea di ricerca 3: Targeting autophagy and fibrosis-related Epigenetic Regulators in Cardiovascular Diseases ECS 0000024 Rome Technopole, CUP B83C22002820006, PNRR Missione 4 Componente 2 Investimento 1.5\u201d, funded by the European Union\u2014Next GenerationEU. Spoke 1, Flagship 7 191250 \u20ac Start date 19\/06\/2022 end date 30\/06\/2025 30%\n<\/td>\n<td>ECS 0000024 Rome Technopole, CUP B83C22002820006, PNRR Missione 4 Componente 2 Investimento 1.5\u201d, funded by the European Union\u2014Next GenerationEU. Spoke 1, Flagship 7 <\/td>\n<td>191.250 <\/td>\n<td>19\/06\/2022-30\/06\/2025 <\/td>\n<td>30% <\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Novel insights on the repurposing of the anthelminthic Mebendazole: identifying the anticancer properties of the chiral forms of reduced Mebendazole in a monitored environment of triple negative breast cancer 3D heterotypic spheroids\n<\/td>\n<td>Istituto Pasteur Italia-Fondazione Cenci Bolognetti <\/td>\n<td>40.000 <\/td>\n<td>01\/03\/2025-28\/02\/2027 <\/td>\n<td>30% <\/td> \n    <\/tr>\n    \n    \n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca88149 elementor-widget elementor-widget-text-editor\" data-id=\"ca88149\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Complete list of published work in MyBibliography: <br><\/b><\/p><p><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=de+falco+e\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=de+falco+e<\/a><\/span><\/p><p><strong> <\/strong><strong>KEYWORDS:<\/strong><\/p><p>Platelet lysate, tissue regeneration, cancer, 3D stem cell niches, angiogenesis, diabetes, cardiovascular diseases and fibrosis, oxidative stress, endothelial cells, extracellular vesicles, mesenchymal stem cells, molecular oncology, drug repurposing.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Elena De Falco Biographical Sketch elena.defalco@uniroma1.it Academic Appointments: 1. Associate Professor (06\/A2 MED\/05)- Full Time University of Rome \u201cSapienza\u201d, Faculty of Pharmacy and Medicine Department of Medical-Surgical Sciences and Biotechnologies, C.so della Repubblica 79, 04100 Latina, Italy 2. Head of Pathologist, Clinical Pathology Unit (UOC), Sapienza University of Rome Istituto Chirurgico Ortopedico Traumatologico ICOT Latina, &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10683,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[192],"tags":[],"class_list":["post-10684","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10684"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10684\/revisions"}],"predecessor-version":[{"id":10685,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10684\/revisions\/10685"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10683"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}