{"id":10695,"date":"2023-02-24T15:06:50","date_gmt":"2023-02-24T14:06:50","guid":{"rendered":"https:\/\/www.istitutopasteuritalia.it\/2023\/15\/musaro-antonio\/"},"modified":"2026-07-16T14:27:05","modified_gmt":"2026-07-16T12:27:05","slug":"musaro-antonio","status":"publish","type":"post","link":"https:\/\/www.istitutopasteuritalia.it\/en\/2023\/15\/musaro-antonio\/","title":{"rendered":"Musar\u00f2 Antonio"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"10695\" class=\"elementor elementor-10695 elementor-5890\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-56585132 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"56585132\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-499c51d5\" data-id=\"499c51d5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-26a8fb5a elementor-widget elementor-widget-spacer\" data-id=\"26a8fb5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bbf095d elementor-widget elementor-widget-heading\" data-id=\"6bbf095d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Antonio Musar\u00f2<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c18445d elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"c18445d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img fetchpriority=\"high\" decoding=\"async\" width=\"540\" height=\"540\" src=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2023\/02\/Musar\u00f2_1.png\" class=\"attachment-full size-full wp-image-10693\" alt=\"\" srcset=\"https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2023\/02\/Musar\u00f2_1.png 540w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2023\/02\/Musar\u00f2_1-150x150.png 150w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2023\/02\/Musar\u00f2_1-300x300.png 300w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2023\/02\/Musar\u00f2_1-359x359.png 359w, https:\/\/www.istitutopasteuritalia.it\/wp-content\/uploads\/2023\/02\/Musar\u00f2_1-60x60.png 60w\" sizes=\"(max-width: 540px) 100vw, 540px\" \/><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\">Full Professor<\/h3><p class=\"elementor-image-box-description\">antonio.musaro@uniroma1.it<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5259bb04 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5259bb04\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-26c7e324\" data-id=\"26c7e324\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a3a6424 elementor-widget elementor-widget-heading\" data-id=\"a3a6424\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Academic Appointments:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b24e87 elementor-widget elementor-widget-text-editor\" data-id=\"2b24e87\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>1996\u22122000 Postdoctoral training\u2212 Research fellow, Cardiovascular Research Center; Harvard University.<\/li><li>1999\u22122007 Assistant professor, Sapienza University of Rome \u2212Medical School.<\/li><li>2003\u22122014 Adjunct Associate Professor (honorary position), School of Biomedical &#038; Sports Science; Faculty of Computing, Health and Science. Edith Cowan University; Western Australia. <\/li><li>2007- Jan 2017 Associate professor, Medical and Biotechnology School, Sapienza University of Rome.<\/li><li>Feb 2017-present Full professor, Medical and Biotechnology School, Sapienza University of Rome<\/li><li>2018-2024 Coordinator of the Ph.D. program in Morphogenesis and Tissue Engineering <\/li><li>2020-present Senior Research Fellow and Coordinator of Life Science academic class, Sapienza School for Advanced Studies (SSAS)<\/li><li>2024-present Director of Master in One Health, Sapienza University of Rome<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-936d34c elementor-widget elementor-widget-heading\" data-id=\"936d34c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Honors and Awards:<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75b7595 elementor-widget elementor-widget-text-editor\" data-id=\"75b7595\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>2003 Award for Scientific Communication (Rotary Club)<\/li><li>2006 Award for Scientific Communication, Foglia di Tabacco<\/li><li>2009 Award Sapienza Ricerca for best research 2009 (Sapienza University of Rome)<\/li><li>2014 La Plejade ANCIS International Award 2014 for Scientific Research <\/li><li>2018 Unitel-Puglia (Pergamena D\u2019onore)<\/li><li>2021 Award \u201cUnion Invictus\u201d for scientific career<\/li><li>2024 Award \u00abAlfredo Margreth\u00bb for Cell Biology, Accademia Nazionale dei Lincei<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb8cb9a elementor-widget elementor-widget-heading\" data-id=\"eb8cb9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Scientific interests\n<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0d676ed elementor-widget elementor-widget-text-editor\" data-id=\"0d676ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">Aging and neuromuscular diseases (ALS, muscular dystrophies); role of stem cells and tissue niche on muscle regeneration.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f484fa8 elementor-widget elementor-widget-heading\" data-id=\"f484fa8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Contribution to Science<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f8fe8b0 elementor-widget elementor-widget-text-editor\" data-id=\"f8fe8b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p class=\"p1\">We study muscle homeostasis and regeneration under normal and pathologic conditions. Although considerable information has accumulated regarding the physiopathology of muscle diseases, the associated molecular mechanisms are still poorly understood. Current data point out that the development of muscle wasting is a multifactorial process and believed to be the result of both intrinsic factors, involving changes in molecular and cellular levels, and extrinsic ones, such as nutrition and exercise. We reported that motor-unit remodelling, decreased hormone levels with consequent negative effect on protein synthesis, stress oxidative damage, alteration in satellite cells activity may all contribute to decrease in muscle mass and functional performance.   <\/p><p class=\"p1\">Our approach entails both hypothesis-driven and data-driven investigations and combines an interdisciplinary set of expertise, ranging from cell, molecular, and biochemical tools, tissue engineering, material science and bio-mechanics approaches.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2e6750e elementor-widget elementor-widget-heading\" data-id=\"2e6750e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-default\">Selected publications<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1028ab elementor-widget elementor-widget-text-editor\" data-id=\"c1028ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul class=\"ol1\"><li class=\"li1\"><strong>Musar\u00f2 A<\/strong>, McCullagh KJ, Naya FJ, Olson EN, Rosenthal N. IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1. Nature. 1999; 400: 581-5.  <\/li><li class=\"li1\"><strong>Musar\u00f2 A<\/strong>, McCullagh K, Paul A, Houghton L, Dobrowolny G, Molinaro M, Barton ER, Sweeney HL, Rosenthal N. Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nature Genetics 2001; 27: 195-200. <\/li><li class=\"li1\">Dobrowolny G, Giacinti C, Pelosi L, Nicoletti C, Winn N, Barberi L, Molinaro M, Rosenthal N, <strong>Musar\u00f2 A<\/strong>. Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. J Cell Biol. 2005; 168:193-9.  <\/li><li class=\"li1\">Dobrowolny G, Aucello M, Rizzuto E, Beccafico S, Mammucari C, Bonconpagni S, Belia S, Wannenes, F Nicoletti, C Del Prete Z, Rosenthal N, Molinaro M, Protasi F, Fan\u00f2 G, Sandri M, and <strong>Musar\u00f2 A<\/strong>. Skeletal muscle is a primary target of SOD1G93A -mediated toxicity Cell Metabolism 2008; 8:425-36. <\/li><li class=\"li1\">Cosentino M, Forcina L, Zouhair M, Apa L, Genovese D, Boccia C, Rizzuto E, <strong>Musar\u00f2 A<\/strong>. Modelling three-dimensional cancer-associated cachexia and therapy: The molecular basis and therapeutic potential of interleukin-6 transignalling blockade. J Cachexia Sarcopenia Muscle. 2023;14(6):2550-2568. doi: 10.1002\/jcsm.13329.    <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-255c65c8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"255c65c8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6e1d00e9\" data-id=\"6e1d00e9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7a60648b elementor-widget elementor-widget-heading\" data-id=\"7a60648b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">On-going Grants <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2136fe5d elementor-widget elementor-widget-html\" data-id=\"2136fe5d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<table class=\"ricercatori-table\">\n    <tr class=\"ricercatori-table-head\">\n        <td>Project Title<\/td>\n <td>Funding Source<\/td>\n <td>Amount\n(Euros)<\/td>\n <td>Period<\/td>\n <td>Role of the PI<\/td> \n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Dissecting mechanisms that cause cancer cachexia <\/td>\n<td>PRIN <\/td>\n<td>85.500 <\/td>\n<td>2024-2026 <\/td>\n<td>PI<\/td>\n    <\/tr>\n    <tr class=\"ricercatori-table-row\">\n        <td>Are sympathetic neurons additional and targetable players in amyotrophic lateral sclerosis (ALS)? <\/td>\n<td>AriSLA <\/td>\n<td>76.700 <\/td>\n<td>2023-2025 <\/td>\n<td>Co-PI<\/td>\n    <\/tr>\n     <tr class=\"ricercatori-table-row\">\n        <td>A translational approach to characterize the muscle-brain interplay in neurological non-communicable diseases. The M-Brain project  <\/td>\n        <td>Ministero della Salute <\/td>\n        <td>218.000  <\/td>\n        <td>2024-2027<\/td>\n        <td>Co-PI<\/td>\n    <\/tr>\n<\/table>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ce2c9ae elementor-widget elementor-widget-text-editor\" data-id=\"1ce2c9ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><span style=\"color: #000000;\">Complete list of published work in MyBibliography:<\/span> <br\/><span style=\"text-decoration: underline;\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=musar%C3%B2+antonio&#038;sort=date\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=musar%C3%B2+antonio&#038;sort=date<\/a><\/span><\/p><p><span style=\"color: #000000;\"><strong>KEYWORDS<\/strong><\/span><\/p><p><span style=\"color: #000000;\">Muscle homeostasis and regeneration, stem cells, neuromuscular diseases, aging, sarcopenia.<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Antonio Musar\u00f2 Full Professor antonio.musaro@uniroma1.it Academic Appointments: 1996\u22122000 Postdoctoral training\u2212 Research fellow, Cardiovascular Research Center; Harvard University. 1999\u22122007 Assistant professor, Sapienza University of Rome \u2212Medical School. 2003\u22122014 Adjunct Associate Professor (honorary position), School of Biomedical &#038; Sports Science; Faculty of Computing, Health and Science. Edith Cowan University; Western Australia. 2007- Jan 2017 Associate professor, Medical &hellip;<\/p>\n","protected":false},"author":2,"featured_media":10694,"comment_status":"open","ping_status":"open","sticky":false,"template":"elementor_header_footer","format":"standard","meta":{"give_campaign_id":0,"footnotes":""},"categories":[193,192],"tags":[],"class_list":["post-10695","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nuovi-finanziati","category-sapienza-researchers-funded-by-istituto-pasteur"],"_links":{"self":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10695","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/comments?post=10695"}],"version-history":[{"count":1,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10695\/revisions"}],"predecessor-version":[{"id":10696,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/posts\/10695\/revisions\/10696"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media\/10694"}],"wp:attachment":[{"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/media?parent=10695"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/categories?post=10695"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.istitutopasteuritalia.it\/en\/wp-json\/wp\/v2\/tags?post=10695"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}